[Comparison of plasma concentrations of amoxicillin administered by oral and venous routes in neonatal bacterial colonizations].

The amoxicillin is a drug that for the incomplete capacity of intestinal absorption in newborn is give for intravenous way. The use of this way and the duration of treatment impose the separation of the newborn from mother and a proportionate preparation of the nurses for the execution of this therapy. We have compared, in newborn infants, with clinical and laboratory diagnosis of neonatal infection, the amoxicillin's plasmatic concentration after intravenous giving and oral giving, in relation to minimum inhibiting concentration the bacteria cause of neonatal infections. In our study (duration 10 months) the newborn infants were perfectly comparable for gestational age, Apgar's score, birthweight, breastfeeding. The newborn infants, at random, were divided in two groups; the first group (18 newborns) received drug for oral way, the second group (14 newborns) for intravenous way. The dosage was 40 mg/Kg/dose of amoxicillin. The duration of treatment was 4 days. Remarkable was the great individual variability of plasmatic concentration of amoxicillin independently from way of giving. The plasmatic concentrations were nearly similar except for the first half hour (plasmatic concentrations after oral giving was lower). The use of oral way is, therefore, favourable for the facility of giving and effective as the intravenous way in the control of neonatal infections.

RCT Entities:   Population Interventions Outcomes