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Literature DB >> 14617748

Therapeutic CD154 antibody for lupus: promise for the future?

Abstract

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease characterized by the production of pathogenic autoantibodies. A new study demonstrates that passive antibody specific for the TNF family member, CD154, ameliorates disease by reducing levels of self-reactive antibody in the serum. This study demonstrates a substantial potential for anti-CD154 antibody in the treatment of humoral autoimmunity.

Entities: Disease Gene

Mesh：

Substances：

Year: 2003 PMID： 14617748 PMCID： PMC259140 DOI： 10.1172/JCI20371

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

22 in total

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2. Cutting edge: germinal centers can be induced in the absence of T cells.

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Journal: J Leukoc Biol Date: 2001-10 Impact factor: 4.962

5. Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus.

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Journal: J Immunol Date: 2001-08-15 Impact factor: 5.422

6. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

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Journal: Cell Date: 2000-09-01 Impact factor: 41.582

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Authors: Kai-Michael Toellner; William E Jenkinson; Dale R Taylor; Mahmood Khan; Daniel M-Y Sze; David M Sansom; Carola G Vinuesa; Ian C M MacLennan
Journal: J Exp Med Date: 2002-02-04 Impact factor: 14.307

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Journal: J Exp Med Date: 2000-02-07 Impact factor: 14.307

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Authors: A J Reed; M P Riley; A J Caton
Journal: J Exp Med Date: 2000-12-18 Impact factor: 14.307

Review 10. Revising B cell receptors.

Authors: D Nemazee; M Weigert
Journal: J Exp Med Date: 2000-06-05 Impact factor: 14.307

4 in total

Review 1. The CD40/CD40L costimulatory pathway in inflammatory bowel disease.

Authors: S Danese; M Sans; C Fiocchi
Journal: Gut Date: 2004-07 Impact factor: 23.059

2. Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.

Authors: Nai-Ying Zheng; Kenneth Wilson; Xiaojian Wang; Angela Boston; Grant Kolar; Stephen M Jackson; Yong-Jun Liu; Virginia Pascual; J Donald Capra; Patrick C Wilson
Journal: J Clin Invest Date: 2004-04 Impact factor: 14.808

3. Abnormal high-expression of CD154 on T lymphocytes of ankylosing spondylitis patients is down-regulated by etanercept treatment.

Authors: Qu Lin; Zhiming Lin; Jieruo Gu; Feng Huang; Tianwang Li; Qiujing Wei; Zetao Liao; Shuangyan Cao; Yingjuan Jiang; Jinxian Huang
Journal: Rheumatol Int Date: 2009-05-23 Impact factor: 2.631

4. Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus.

Authors: Ramya Sivakumar; Georges Abboud; Clayton E Mathews; Mark A Atkinson; Laurence Morel
Journal: Front Immunol Date: 2018-05-09 Impact factor: 7.561

4 in total