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Literature DB >> 1461736

The histone mRNA 3' end is required for localization of histone mRNA to polyribosomes.

Abstract

The final step in mRNA biosynthesis is transport of the mRNA from the nucleus to the cytoplasm. Histone genes from which the 3' stem-loop has been deleted are transcribed to give RNAs with heterogeneous 3' ends. These RNAs are localized in the nucleus and are stable. Addition of the histone 3' processing signal either on short (< 250 nts) or long (> 1000 nts) transcripts restores 3' processing and transport of the mRNA to the cytoplasm. In addition chimeric histone-U1 snRNA genes which produced RNAs with either histone or U1 3' ends were analyzed. Transcripts which ended with U1 snRNA 3' ends were not efficiently localized to polyribosomes. However, transcripts containing the same sequences including the snRNA 3' end followed by the histone 3' end were present in the cytoplasm on polyribosomes. Taken together these results suggest that the histone 3' end is required for export of histone mRNA to the cytoplasm and association of the mRNA with polyribosomes.

Entities: Gene

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Year: 1992 PMID： 1461736 PMCID： PMC334473 DOI： 10.1093/nar/20.22.6057

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

57 in total

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Journal: Cell Date: 1986-10-24 Impact factor: 41.582

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Journal: Cell Date: 1986-09-12 Impact factor: 41.582

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Journal: Mol Cell Biol Date: 1985-09 Impact factor: 4.272

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Journal: J Mol Biol Date: 1985-05-25 Impact factor: 5.469

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Journal: Nucleic Acids Res Date: 1989-11-25 Impact factor: 16.971

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Journal: EMBO J Date: 1990-11 Impact factor: 11.598

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Authors: P Bernstein; J Ross
Journal: Trends Biochem Sci Date: 1989-09 Impact factor: 13.807

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Journal: EMBO J Date: 1989-12-01 Impact factor: 11.598

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Authors: B Lüscher; D Schümperli
Journal: EMBO J Date: 1987-06 Impact factor: 11.598

31 in total

1. Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid system.

Authors: F Martin; F Michel; D Zenklusen; B Müller; D Schümperli
Journal: Nucleic Acids Res Date: 2000-04-01 Impact factor: 16.971

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Authors: F Martin; A Schaller; S Eglite; D Schümperli; B Müller
Journal: EMBO J Date: 1997-02-17 Impact factor: 11.598

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Journal: Experientia Date: 1995-06-14

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Journal: Mol Cell Biol Date: 1998-10 Impact factor: 4.272

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Authors: Z F Wang; T C Ingledue; Z Dominski; R Sanchez; W F Marzluff
Journal: Mol Cell Biol Date: 1999-01 Impact factor: 4.272