Literature DB >> 14616684

Community-acquired pneumonia: causes of treatment failure in patients enrolled in clinical trials.

D Genné1, L Kaiser, T N Kinge, D Lew.   

Abstract

In order to determine the causes of treatment failure in community-acquired pneumonia (CAP) clinical trials, a MEDLINE search for all CAP studies published between 1990 and 1997 was performed. Prospective, randomized studies comparing the efficacy of two or more antibiotics in CAP were selected. Treatment failure was defined as persistent fever, deterioration of patient's condition, or a change in the prescribed antibiotic regimen. In 16% of the cases included in the clinical trials, the treatment of CAP is unsuccessful. A significant number of identified failure cases were owing to antibiotic side-effects. Resistant pathogens are an unusual cause of failure whatever the antibiotic used.

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Year:  2003        PMID： 14616684     DOI： 10.1046/j.1469-0691.2003.00679.x

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  8 in total

1.  The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America.

Authors:  John S Bradley; Carrie L Byington; Samir S Shah; Brian Alverson; Edward R Carter; Christopher Harrison; Sheldon L Kaplan; Sharon E Mace; George H McCracken; Matthew R Moore; Shawn D St Peter; Jana A Stockwell; Jack T Swanson
Journal:  Clin Infect Dis       Date:  2011-08-31       Impact factor: 9.079

Review 2.  Predictors of treatment failure and clinical stability in patients with community acquired pneumonia.

Authors:  Deirdre Morley; Antoni Torres; Catia Cillóniz; Ignacio Martin-Loeches
Journal:  Ann Transl Med       Date:  2017-11

3.  Procalcitonin and pneumonia: is it a useful marker?

Authors:  Mirjam Christ-Crain; Beat Müller
Journal:  Curr Infect Dis Rep       Date:  2007-05       Impact factor: 3.725

4.  Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected Pneumonia.

Authors:  Matthew J Lipshaw; Michelle Eckerle; Todd A Florin; Eric J Crotty; Jessi Lipscomb; Judd Jacobs; Mantosh S Rattan; Richard M Ruddy; Samir S Shah; Lilliam Ambroggio
Journal:  Pediatrics       Date:  2020-03-16       Impact factor: 7.124

5.  Analysis of factors that contribute to treatment failure in patients with community-acquired pneumonia.

Authors:  D Genné; R Sommer; L Kaiser; A Saaïdia; A Pasche; P F Unger; D Lew
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2006-03       Impact factor: 3.267

6.  Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia.

Authors:  Beat Müller; Stephan Harbarth; Daiana Stolz; Roland Bingisser; Christian Mueller; Jörg Leuppi; Charly Nusbaumer; Michael Tamm; Mirjam Christ-Crain
Journal:  BMC Infect Dis       Date:  2007-03-02       Impact factor: 3.090

Review 7.  [Community acquired pneumonia CAP].

Authors:  Christoph Wenisch; Christine M Bonelli
Journal:  Wien Klin Wochenschr       Date:  2006-12       Impact factor: 1.704

8.  Factors Associated With Treatment Failure in Moderately Severe Community-Acquired Pneumonia: A Secondary Analysis of a Randomized Clinical Trial.

Authors:  Aurélien Dinh; Clara Duran; Jacques Ropers; Frédérique Bouchand; Benjamin Davido; Laurène Deconinck; Morgan Matt; Olivia Senard; Aurore Lagrange; Guillaume Mellon; Ruxandra Calin; Sabrina Makhloufi; Victoire de Lastours; Emmanuel Mathieu; Jean-Emmanuel Kahn; Elisabeth Rouveix; Julie Grenet; Jennifer Dumoulin; Thierry Chinet; Marion Pépin; Véronique Delcey; Sylvain Diamantis; Daniel Benhamou; Virginie Vitrat; Marie-Christine Dombret; Didier Guillemot; Bertrand Renaud; Yann-Erick Claessens; José Labarère; Philippe Aegerter; Jean-Pierre Bedos; Anne-Claude Crémieux
Journal:  JAMA Netw Open       Date:  2021-10-01
  8 in total

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