Literature DB >> 14616421

Nitrate tolerance and the links with endothelial dysfunction and oxidative stress.

Katherine E Fayers1, Michael H Cummings, Kenneth M Shaw, David W Laight.   

Abstract

Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.

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Year:  2003        PMID： 14616421      PMCID： PMC1884304          DOI： 10.1046/j.1365-2125.2003.01946.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  79 in total

Review 1.  Nitrate tolerance: a unifying hypothesis.

Authors:  Tommaso Gori; John D Parker
Journal:  Circulation       Date:  2002-11-05       Impact factor: 29.690

Review 2.  The puzzle of nitrate tolerance: pieces smaller than we thought?

Authors:  Tommaso Gori; John D Parker
Journal:  Circulation       Date:  2002-10-29       Impact factor: 29.690

3.  Vitamin E supplementation and cardiovascular events in high-risk patients.

Authors:  S Yusuf; G Dagenais; J Pogue; J Bosch; P Sleight
Journal:  N Engl J Med       Date:  2000-01-20       Impact factor: 91.245

4.  A short history of nitroglycerine and nitric oxide in pharmacology and physiology.

Authors:  N Marsh; A Marsh
Journal:  Clin Exp Pharmacol Physiol       Date:  2000-04       Impact factor: 2.557

5.  Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability.

Authors:  T Münzel; H Li; H Mollnau; U Hink; E Matheis; M Hartmann; M Oelze; M Skatchkov; A Warnholtz; L Duncker; T Meinertz; U Förstermann
Journal:  Circ Res       Date:  2000-01-07       Impact factor: 17.367

6.  Vascular peroxynitrite formation during organic nitrate tolerance.

Authors:  M J Mihm; C M Coyle; L Jing; J A Bauer
Journal:  J Pharmacol Exp Ther       Date:  1999-10       Impact factor: 4.030

7.  Identification of the enzymatic mechanism of nitroglycerin bioactivation.

Authors:  Zhiqiang Chen; Jian Zhang; Jonathan S Stamler
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-04       Impact factor: 11.205

Review 8.  Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.

Authors:  J Leiper; P Vallance
Journal:  Cardiovasc Res       Date:  1999-08-15       Impact factor: 10.787

9.  Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Authors:  S Rajagopalan; S Kurz; T Münzel; M Tarpey; B A Freeman; K K Griendling; D G Harrison
Journal:  J Clin Invest       Date:  1996-04-15       Impact factor: 14.808

10.  MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial.

Authors: 
Journal:  Lancet       Date:  2002-07-06       Impact factor: 79.321
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  5 in total

Review 1.  Novel therapeutic targets for preserving a healthy endothelium: strategies for reducing the risk of vascular and cardiovascular disease.

Authors:  Joseph Ramli; Pedro CalderonArtero; Robert C Block; Shaker A Mousa
Journal:  Cardiol J       Date:  2011       Impact factor: 2.737

2.  Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome.

Authors:  Mark T Gladwin
Journal:  J Clin Invest       Date:  2006-09       Impact factor: 14.808

3.  Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.

Authors:  Barbara K Kemp-Harper; Anida Velagic; Nazareno Paolocci; John D Horowitz; Rebecca H Ritchie
Journal:  Handb Exp Pharmacol       Date:  2021

Review 4.  Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate.

Authors:  Matthias Oelze; Swenja Schuhmacher; Andreas Daiber
Journal:  Exp Diabetes Res       Date:  2010-12-27

5.  Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy.

Authors:  Swenja Schuhmacher; Matthias Oelze; Franziska Bollmann; Hartmut Kleinert; Christian Otto; Tjebo Heeren; Sebastian Steven; Michael Hausding; Maike Knorr; Andrea Pautz; Kurt Reifenberg; Eberhard Schulz; Tommaso Gori; Philip Wenzel; Thomas Münzel; Andreas Daiber
Journal:  Diabetes       Date:  2011-08-15       Impact factor: 9.461
  5 in total

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