Literature DB >> 14614849

Amplifying Btk's signal.

Pamela L Schwartzberg1.   

Abstract

The Tec kinase Btk is an important regulator of antigen receptor activation of phospholipase C-gamma (PLC-gamma). Data from Carpenter and colleagues (Saito et al., this issue of Immunity) now suggest that Btk also activates phosphatidylinositol-4-phosphate 5-kinase (PIP5K), thereby stimulating a positive feedback loop that generates PI(4,5)P2, the substrate for both phosphoinositide 3-kinase (PI3K) and PLC-gamma.

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Year:  2003        PMID： 14614849     DOI： 10.1016/s1074-7613(03)00304-2

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  4 in total

1.  Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.

Authors:  Martin Wist; Laura Meier; Orit Gutman; Jennifer Haas; Sascha Endres; Yuan Zhou; Reinhild Rösler; Sebastian Wiese; Stephan Stilgenbauer; Elias Hobeika; Yoav I Henis; Peter Gierschik; Claudia Walliser
Journal:  J Biol Chem       Date:  2020-03-17       Impact factor: 5.157

2.  Particles from the Echinococcus granulosus Laminated Layer Inhibit CD40 Upregulation in Dendritic Cells by Interfering with Akt Activation.

Authors:  Álvaro Pittini; Yamila E Martínez-Acosta; Cecilia Casaravilla; Paula I Seoane; Dominik Rückerl; Celia Quijano; Judith E Allen; Álvaro Díaz
Journal:  Infect Immun       Date:  2019-11-18       Impact factor: 3.441

3.  Differential role of hypoxia-inducible factor 1 alpha in toll-like receptor-mediated and allergic inflammatory reactions.

Authors:  Vadim V Sumbayev; Sally A Nicholas; Bernhard F Gibbs
Journal:  World Allergy Organ J       Date:  2010-10       Impact factor: 4.084

4.  Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.

Authors:  Julio Gomez-Rodriguez; Elizabeth A Wohlfert; Robin Handon; Françoise Meylan; Julie Z Wu; Stacie M Anderson; Martha R Kirby; Yasmine Belkaid; Pamela L Schwartzberg
Journal:  J Exp Med       Date:  2014-02-17       Impact factor: 14.307
  4 in total

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