| Literature DB >> 14613774 |
Dirk Roos1, Robin van Bruggen, Christof Meischl.
Abstract
Neutrophils and other phagocytic leukocytes contain a phagocyte NADPH oxidase enzyme that generates superoxide after cell activation. Reactive oxygen species derived from superoxide, together with proteases liberated from the granules, are used to kill ingested microbes. Dysfunction of the phagocyte NADPH oxidase results in chronic granulomatous disease, with life-threatening infections.Entities:
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Year: 2003 PMID: 14613774 DOI: 10.1016/j.micinf.2003.09.009
Source DB: PubMed Journal: Microbes Infect ISSN: 1286-4579 Impact factor: 2.700