| Literature DB >> 14613314 |
Yanping Xu1, Daniel Mayhugh, Ashraf Saeed, Xiaodong Wang, Richard C Thompson, Samuel J Dominianni, Raymond F Kauffman, Jaipal Singh, James S Bean, William R Bensch, Robert J Barr, John Osborne, Chahrzad Montrose-Rafizadeh, Richard W Zink, Nathan P Yumibe, Naijia Huang, Debra Luffer-Atlas, Deepa Rungta, Dale E Maise, Nathan B Mantlo.
Abstract
A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist.Entities:
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Year: 2003 PMID： 14613314 DOI： 10.1021/jm034173l
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446