| Literature DB >> 14613313 |
María J Vázquez1, Ana M Roa, Fernando Reyes, Alfonso Vega, Alfonso Rivera-Sagredo, David R Thomas, Emilio Díez, Juan A Hueso-Rodríguez.
Abstract
In the course of a search for small-molecule inhibitors of 5-hydroxytryptamine receptors we have identified a novel ergoline derivative (1) from the fungal culture of Dicyma sp. This compound has a pK(i) of 10.2 versus the 5-hydroxytryptamine(1A) receptor subtype. The structure was elucidated by extensive NMR spectroscopy and mass spectrometry.Entities:
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Year: 2003 PMID： 14613313 DOI： 10.1021/jm0341204
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446