| Literature DB >> 14613000 |
Hélène LaRue1, Maryse Simoneau, Tahar O Aboulkassim, Patricia Lemieux, Johanne Girard, Sahar Hamed, Hélène Hovington, Lucie Jeannotte, Yves Fradet.
Abstract
Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. Loss of heterozygosity at position 9q22.3 is one of the most frequent and is associated with highly recurrent tumours. The PATCHED gene, ortholog of a gene first described in the drosophila as a segment polarity gene, is located at 9q22.3. It is a member of a signal transduction pathway and a tumour suppressor gene (TSG), involved in basal cell carcinoma. We propose PATCHED as a TSG candidate in superficial bladder cancer.Entities:
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Year: 2003 PMID： 14613000 DOI： 10.1051/medsci/20031910920
Source DB: PubMed Journal: Med Sci (Paris) ISSN： 0767-0974 Impact factor: 0.818