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Literature DB >> 14612494

Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease.

Alexander O Vortmeyer¹, Stephan Frank, Seon-Yong Jeong, Kristy Yuan, Barbara Ikejiri, Youn-Soo Lee, Deb Bhowmick, Russell R Lonser, Reginald Smith, Griffin Rodgers, Edward H Oldfield, Zhengping Zhuang.

Abstract

The nature of the cell responsible for von Hippel-Lindau (VHL) disease-associated tumor formation has been controversial for decades. We demonstrate that VHL disease-associated central nervous system tumors are composed of developmentally arrested angioblasts that coexpress erythropoietin (Epo) and Epo receptor. The angioblasts are capable of differentiating into RBCs via formation of blood islands with extramedullary hematopoiesis. Because of VHL deficiency, Epo receptor-expressing, developmentally arrested angioblasts simultaneously coexpress Epo, which may represent a crucial pathogenetic step in tumor formation.

Entities: Disease Gene

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Year: 2003 PMID： 14612494

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

43 in total

1. Neurological surgery at the National Institutes of Health.

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2. CD41 and CD45 expression marks the angioformative initiation of neovascularisation in human haemangioblastoma.

Authors: Dexuan Ma; Ying Wang; Guhong Du; Jingyun Yang; Qisheng Tang; Liangfu Zhou
Journal: Tumour Biol Date: 2015-10-14

3. VHL-deficient vasculogenesis in hemangioblastoma.

Authors: Sven Gläsker; Jonathan Smith; Mark Raffeld; Jie Li; Edward H Oldfield; Alexander O Vortmeyer
Journal: Exp Mol Pathol Date: 2014-01-04 Impact factor: 3.362

4. Selection of surgical approach for cerebellar hemangioblastomas based on venous drainage patterns.

Authors: Takashi Watanabe; Yuuki Suematsu; Kiyotaka Saito; Go Takeishi; Shinji Yamashita; Hajime Ohta; Kiyotaka Yokogami; Hideo Takeshima
Journal: Neurosurg Rev Date: 2021-04-20 Impact factor: 3.042

5. Podoplanin is expressed in subsets of tumors of the central nervous system.

Authors: Junji Shibahara; Takeshi Kashima; Yoshinao Kikuchi; Akiko Kunita; Masashi Fukayama
Journal: Virchows Arch Date: 2006-01-13 Impact factor: 4.064

6. Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas.

Authors: David Taïeb; Anne Barlier; Chunzhang Yang; Morgane Pertuit; Aurélie Tchoghandjian; Claire Rochette; Hélène Zattara-Canoni; Dominique Figarella-Branger; Zhengping Zhuang; Karel Pacak; Philippe Metellus
Journal: J Neurooncol Date: 2015-10-29 Impact factor: 4.130

Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease.

1. Neurological surgery at the National Institutes of Health.

2. CD41 and CD45 expression marks the angioformative initiation of neovascularisation in human haemangioblastoma.

3. VHL-deficient vasculogenesis in hemangioblastoma.

4. Selection of surgical approach for cerebellar hemangioblastomas based on venous drainage patterns.

5. Podoplanin is expressed in subsets of tumors of the central nervous system.

6. Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas.

Review 7. Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review.

8. Von Hippel-Lindau gene deletion and expression of hypoxia-inducible factor and ubiquitin in optic nerve hemangioma.

Review 9. Central nervous system capillary haemangioblastoma: the pathologist's viewpoint.

10. Neuro-ophthalmology of von Hippel-Lindau.