| Literature DB >> 14611947 |
Dorothea Besch1, Herbert Jägle, Hendrik P N Scholl, Mathias W Seeliger, Eberhart Zrenner.
Abstract
Alterations of retinoid cycle genes are known to cause retinal diseases characterized by focal white dot fundus lesions. Fundus appearances reveal circumscribed RPE-changes, although generalized metabolic defects and global functional abnormalities are present. As a possible explanation, topographic inhomogeneities of the human photoreceptor mosaic and the role of a cone specific visual cycle will be discussed. Due to particular characteristics of photoreceptor subtypes as well as different pathways for photopigment regeneration the metabolic demand of individual RPE cells might differ. In "flecked retina diseases" heterogeneity of metabolic demand in individual RPE cells could therefore be responsible for their multifocal appearance.Entities:
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Year: 2003 PMID： 14611947 DOI： 10.1016/j.visres.2003.09.020
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886