Literature DB >> 14611942

Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein.

Ekaterina M Semenova1, Carolyn A Converse.   

Abstract

Interphotoreceptor retinoid-binding protein (IRBP), which binds retinoids and fatty acids, is the major soluble protein in the interphotoreceptor matrix (IPM) but its role remains ambiguous. Using competitive fluorescence and tryptophan-quenching assays we found oleic acid and other cis-monounsaturated fatty acids bind much more strongly than does docosahexaenoic acid to bovine IRBP. IPM's fatty acid composition was determined: it was richer in oleic acid than either the retinal pigment epithelium or rod outer segments. This may imply oleic acid has a key role in the balance and transport of retinoids and fatty acids in the retina.

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Year:  2003        PMID： 14611942     DOI： 10.1016/j.visres.2003.09.008

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  9 in total

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3.  Retinol-binding site in interphotoreceptor retinoid-binding protein (IRBP): a novel hydrophobic cavity.

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Journal:  Invest Ophthalmol Vis Sci       Date:  2009-07-15       Impact factor: 4.799

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Authors:  Debashis Ghosh; Karen M Haswell; Molly Sprada; Federico Gonzalez-Fernandez
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6.  The comparative protective effects of ganoderma spores lipid and fish oil on N-methyl-N-nitrosourea-induced photoreceptor cell lesion in rats.

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Journal:  Evid Based Complement Alternat Med       Date:  2011-05-18       Impact factor: 2.629

Review 7.  Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease.

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8.  Purification of the full-length Xenopus interphotoreceptor retinoid binding protein and growth of diffraction-quality crystals.

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  9 in total

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