Literature DB >> 14611935

Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms.

Jay M Janz1, David L Farrens.   

Abstract

The stability of the retinal chromophore attachment varies between different visual pigments and may factor in some retinal disease states. Opsin appears to stabilize this Schiff base linkage by: (i) affecting the hydrolysis chemistry, (ii) shielding the retinal linkage from solvent, or (iii) acting as a kinetic trap to slow retinal release. Here we describe methods to determine Schiff base stability in rhodopsin, present examples of dark state and MII rhodopsin stability differences, and show that studies of mutants E113Q and D190N demonstrate different parts of rhodopsin influence Schiff base stability in different ways.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14611935     DOI： 10.1016/j.visres.2003.08.010

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  18 in total

1.  Coupling of retinal isomerization to the activation of rhodopsin.

Authors:  Ashish B Patel; Evan Crocker; Markus Eilers; Amiram Hirshfeld; Mordechai Sheves; Steven O Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-25       Impact factor: 11.205

2.  How a small change in retinal leads to G-protein activation: initial events suggested by molecular dynamics calculations.

Authors:  Paul S Crozier; Mark J Stevens; Thomas B Woolf
Journal:  Proteins       Date:  2007-02-15

3.  Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.

Authors:  Christopher T Schafer; Jonathan F Fay; Jay M Janz; David L Farrens
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-04       Impact factor: 11.205

4.  Thermal stability of rhodopsin and progression of retinitis pigmentosa: comparison of S186W and D190N rhodopsin mutants.

Authors:  Monica Yun Liu; Jian Liu; Devi Mehrotra; Yuting Liu; Ying Guo; Pedro A Baldera-Aguayo; Victoria L Mooney; Adel M Nour; Elsa C Y Yan
Journal:  J Biol Chem       Date:  2013-04-26       Impact factor: 5.157

5.  Rapid release of retinal from a cone visual pigment following photoactivation.

Authors:  Min-Hsuan Chen; Colleen Kuemmel; Robert R Birge; Barry E Knox
Journal:  Biochemistry       Date:  2012-05-07       Impact factor: 3.162

6.  Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations.

Authors:  Christopher T Schafer; Anthony Shumate; David L Farrens
Journal:  J Biol Chem       Date:  2020-10-06       Impact factor: 5.157

Review 7.  Constitutively active rhodopsin and retinal disease.

Authors:  Paul Shin-Hyun Park
Journal:  Adv Pharmacol       Date:  2014

8.  A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor.

Authors:  Li Zhu; Geeng-Fu Jang; Beata Jastrzebska; Slawomir Filipek; Susan E Pearce-Kelling; Gustavo D Aguirre; Ronald E Stenkamp; Gregory M Acland; Krzysztof Palczewski
Journal:  J Biol Chem       Date:  2004-09-30       Impact factor: 5.157

9.  Dark noise and retinal degeneration from D190N-rhodopsin.

Authors:  Daniel Silverman; Zuying Chai; Wendy W S Yue; Sravani Keerthi Ramisetty; Sowmya Bekshe Lokappa; Kazumi Sakai; Rikard Frederiksen; Parinaz Bina; Stephen H Tsang; Takahiro Yamashita; Jeannie Chen; King-Wai Yau
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-01       Impact factor: 11.205

10.  Early structural anomalies observed by high-resolution imaging in two related cases of autosomal-dominant retinitis pigmentosa.

Authors:  Sung Pyo Park; Winston Lee; Eun Jin Bae; Vivianne Greenstein; Bum Ho Sin; Stanley Chang; Stephen H Tsang
Journal:  Ophthalmic Surg Lasers Imaging Retina       Date:  2014 Sep-Oct       Impact factor: 1.300
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.