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Literature DB >> 14611934

A2E, a byproduct of the visual cycle.

Janet R Sparrow¹, Nathan Fishkin, Jilin Zhou, Bolin Cai, Young P Jang, Sonja Krane, Yasuhiro Itagaki, Koji Nakanishi.

Abstract

A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation.

Entities: Chemical Disease

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Year: 2003 PMID： 14611934 DOI： 10.1016/s0042-6989(03)00475-9

Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886

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Cited

96 in total

1. Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

Authors: So Ra Kim; Nathan Fishkin; Jian Kong; Koji Nakanishi; Rando Allikmets; Janet R Sparrow
Journal: Proc Natl Acad Sci U S A Date: 2004-07-26 Impact factor: 11.205

2. Palmitoylation stabilizes unliganded rod opsin.

Authors: Akiko Maeda; Kiichiro Okano; Paul S-H Park; Janis Lem; Rosalie K Crouch; Tadao Maeda; Krzysztof Palczewski
Journal: Proc Natl Acad Sci U S A Date: 2010-04-19 Impact factor: 11.205

Review 3. Advances in imaging of Stargardt disease.

Authors: Y Chen; A Roorda; J L Duncan
Journal: Adv Exp Med Biol Date: 2010 Impact factor: 2.622

4. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.

Authors: Ana J Chucair-Elliott; Michael H Elliott; Jiangang Wang; Gennadiy P Moiseyev; Jian-Xing Ma; Luis E Politi; Nora P Rotstein; Shizuo Akira; Satoshi Uematsu; John D Ash
Journal: J Biol Chem Date: 2012-05-29 Impact factor: 5.157

A2E, a byproduct of the visual cycle.

1. Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

2. Palmitoylation stabilizes unliganded rod opsin.

Review 3. Advances in imaging of Stargardt disease.

4. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.

5. Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.

6. Influence of Arrestin on the Photodecay of Bovine Rhodopsin.

7. Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells.

Review 8. Age-related macular degeneration: genetics and biology coming together.

9. In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic.

10. Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats.