Literature DB >> 14611885

Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II.

R R Chattopadhyay1.   

Abstract

Hepatoprotective activity of Azadirachta indica leaf extract against paracetamol induced hepatic damage in rats has already been reported. In the present investigation effects of Azadirachta indica leaf extract on blood and liver glutathione, Na+K(+)-ATPase activity and thiobarbutiric acid reactive substances against paracetamol induced hepatic damage in rats have been studied with a view to elucidate possible mechanism behind its hepatoprotective action. It was interesting to observe that Azadirachta indica leaf extract has reversal effects on the levels of above mentioned parameters in paracetamol hepatotoxicity. Possible mechanism behind the results are discussed.

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Year:  2003        PMID： 14611885     DOI： 10.1016/j.jep.2003.08.006

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  41 in total

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8.  Antioxidant and hepatoprotective effects of flower extract of Millingtonia hortensis Linn. on carbon tetrachloride induced hepatotoxicity.

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9.  Hepatoprotective effect of biherbal ethanolic extract against paracetamol-induced hepatic damage in albino rats.

Authors:  Krishna Chaitanya D Anantha; Reddy Challa Siva; Reddy A Manohar
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