Literature DB >> 14611849

Differentially functionalized diamines as novel ligands for the NPY2 receptor.

Charles J Andres1, Ildiko Antal Zimanyi, Milind S Deshpande, Lawrence G Iben, Katharine Grant-Young, Gail K Mattson, Weixu Zhai.   

Abstract

The synthesis of novel ligands for the NPY(2) receptor using solid phase split pool methodology is described. One of the analogues, diamine 16, was found to be a potent NPY(2) binder.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14611849     DOI： 10.1016/s0960-894x(03)00554-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening.

Authors:  Shaun P Brothers; S Adrian Saldanha; Timothy P Spicer; Michael Cameron; Becky A Mercer; Peter Chase; Patricia McDonald; Claes Wahlestedt; Peter S Hodder
Journal:  Mol Pharmacol       Date:  2009-10-16       Impact factor: 4.436

2.  Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.

Authors:  Gopi Kumar Mittapalli; Danielle Vellucci; Jun Yang; Marion Toussaint; Shaun P Brothers; Claes Wahlestedt; Edward Roberts
Journal:  Bioorg Med Chem Lett       Date:  2012-04-30       Impact factor: 2.823

3.  In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.

Authors:  James R Shoblock; Natalie Welty; Diane Nepomuceno; Brian Lord; Leah Aluisio; Ian Fraser; S Timothy Motley; Steve W Sutton; Kirsten Morton; Ruggero Galici; John R Atack; Lisa Dvorak; Devin M Swanson; Nicholas I Carruthers; Curt Dvorak; Timothy W Lovenberg; Pascal Bonaventure
Journal:  Psychopharmacology (Berl)       Date:  2009-12-02       Impact factor: 4.530

Review 4.  Ligands of the neuropeptide Y Y2 receptor.

Authors:  Gopi Kumar Mittapalli; Edward Roberts
Journal:  Bioorg Med Chem Lett       Date:  2013-12-04       Impact factor: 2.823
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.