| Literature DB >> 14611841 |
Valérie Marcq1, Catherine Mirand, Martine Decarme, Hervé Emonard, William Hornebeck.
Abstract
Some ilomastat analogues featuring an isobutylidene group or a 2-substituted indole nucleus were synthesized to evaluate their inhibitory activities against gelatinase A and stromelysin-1. Potent MMP-2 inhibition and good selectivity for that enzyme have been observed for compounds 1a, 2 and 22.Entities:
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Year: 2003 PMID： 14611841 DOI： 10.1016/s0960-894x(03)00590-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823