Literature DB >> 14610289

IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity.

Mary Collins1, Matthew J Whitters, Deborah A Young.   

Abstract

Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R, that pairs with the gamma-common cytokine receptor chain. The first experiments examining the biology of the IL-21 pathway reveal that it is a cytokine with effects on natural killer (NK) cells, T cells, and B cells. Mice deficient in the IL-21R have also been made, and are being examined for the effects of the IL-21/IL-21R pathway in vivo. Here we summarize our current knowledge of this new cytokine pathway, and its role in innate and adaptive immunity.

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Year:  2003        PMID： 14610289     DOI： 10.1385/IR:28:2:131

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  21 in total

1.  Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells.

Authors:  Ester M van Leeuwen; Laila E Gamadia; Paul A Baars; Ester B Remmerswaal; Ineke J ten Berge; René A van Lier
Journal:  J Immunol       Date:  2002-11-15       Impact factor: 5.422

2.  Structural design and molecular evolution of a cytokine receptor superfamily.

Authors:  J F Bazan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 3.  Jaks and STATs: biological implications.

Authors:  W J Leonard; J J O'Shea
Journal:  Annu Rev Immunol       Date:  1998       Impact factor: 28.527

4.  Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.

Authors:  H Asao; C Okuyama; S Kumaki; N Ishii; S Tsuchiya; D Foster; K Sugamura
Journal:  J Immunol       Date:  2001-07-01       Impact factor: 5.422

Review 5.  IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels.

Authors:  Y Tagaya; R N Bamford; A P DeFilippis; T A Waldmann
Journal:  Immunity       Date:  1996-04       Impact factor: 31.745

6.  Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.

Authors:  K Ozaki; K Kikly; D Michalovich; P R Young; W J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

7.  IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response.

Authors:  Mari Strengell; Timo Sareneva; Don Foster; Ilkka Julkunen; Sampsa Matikainen
Journal:  J Immunol       Date:  2002-10-01       Impact factor: 5.422

8.  The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.

Authors:  Tania Habib; Shantha Senadheera; Kenneth Weinberg; Kenneth Kaushansky
Journal:  Biochemistry       Date:  2002-07-09       Impact factor: 3.162

9.  Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses.

Authors:  Frann Bennett; Deborah Luxenberg; Vincent Ling; I-Ming Wang; Kim Marquette; David Lowe; Nighat Khan; Geertruida Veldman; Kenneth A Jacobs; Viia E Valge-Archer; Mary Collins; Beatriz M Carreno
Journal:  J Immunol       Date:  2003-01-15       Impact factor: 5.422

10.  Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.

Authors:  Andrea L Wurster; Vikki L Rodgers; Abhay R Satoskar; Matthew J Whitters; Deborah A Young; Mary Collins; Michael J Grusby
Journal:  J Exp Med       Date:  2002-10-07       Impact factor: 14.307
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  12 in total

1.  Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.

Authors:  G Monteleone; R Caruso; D Fina; I Peluso; V Gioia; C Stolfi; M C Fantini; F Caprioli; R Tersigni; L Alessandroni; T T MacDonald; F Pallone
Journal:  Gut       Date:  2006-05-08       Impact factor: 23.059

2.  The IL-21 receptor augments Th2 effector function and alternative macrophage activation.

Authors:  John Pesce; Mallika Kaviratne; Thirumalai R Ramalingam; Robert W Thompson; Joseph F Urban; Allen W Cheever; Deborah A Young; Mary Collins; Michael J Grusby; Thomas A Wynn
Journal:  J Clin Invest       Date:  2006-06-15       Impact factor: 14.808

3.  Neutralizing FGF4 protein in conditioned medium of IL-21-silenced HCT116 cells restores the migratory activity of the colorectal cancer cells.

Authors:  Eshtiyag Abdalla Abdalkareem; Ching Yi Ong; Boon Huat Lim; Boon Yin Khoo
Journal:  Cytotechnology       Date:  2018-05-25       Impact factor: 2.058

4.  Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages.

Authors:  F Vallières; D Girard
Journal:  Clin Exp Immunol       Date:  2016-11-22       Impact factor: 4.330

Review 5.  Targeting interleukin-21 in rheumatoid arthritis.

Authors:  Feng-Lai Yuan; Wei Hu; Wei-Guo Lu; Xia Li; Jian-Ping Li; Rui-Sheng Xu; Cheng-Wan Li; Fei-Hu Chen; Cheng Jin
Journal:  Mol Biol Rep       Date:  2010-09-17       Impact factor: 2.316

6.  Tumor immunotherapy: New aspects of natural killer cells.

Authors:  Yangxi Li; Rui Sun
Journal:  Chin J Cancer Res       Date:  2018-04       Impact factor: 5.087

7.  TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.

Authors:  Yun Liu; Sifei Yu; Zitao Li; Jiangjun Ma; Yannan Zhang; Hui Wang; Binyan Yang; Changyou Wu
Journal:  PLoS One       Date:  2013-05-31       Impact factor: 3.240

8.  Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model.

Authors:  Hong He; Preya Wisner; Guojun Yang; Hong-Ming Hu; Dan Haley; William Miller; Aisling O'Hara; W Gregory Alvord; Christopher H Clegg; Bernard A Fox; Walter J Urba; Edwin B Walker
Journal:  J Transl Med       Date:  2006-06-13       Impact factor: 5.531

9.  Melanoma-restricted genes.

Authors:  Ena Wang; Monica C Panelli; Katia Zavaglia; Susanna Mandruzzato; Nan Hu; Phil R Taylor; Barbara Seliger; Paola Zanovello; Ralph S Freedman; Francesco M Marincola
Journal:  J Transl Med       Date:  2004-10-15       Impact factor: 5.531

10.  A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Authors:  Peter C L Beverley; Zsolt Ruzsics; Ariann Hey; Claire Hutchings; Simone Boos; Beatrice Bolinger; Emanuele Marchi; Geraldine O'Hara; Paul Klenerman; Ulrich H Koszinowski; Elma Z Tchilian
Journal:  J Immunol       Date:  2014-07-28       Impact factor: 5.422
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