Literature DB >> 14610139

A randomized trial of botulinum toxin A for treatment of drooling.

A Lipp1, T Trottenberg, T Schink, A Kupsch, G Arnold.   

Abstract

The authors compared the efficacy of three different doses (18.75, 37.5, and 75 MU per parotid gland) of botulinum toxin A (BTX-A; Dysport, Ipsen Pharma, Germany) injections vs vehicle in patients with sialorrhea (n = 32) using a single-center, prospective, double-blind, placebo-controlled dose-finding study. The primary endpoint was achieved with 75 MU BTX-A without treatment-related adverse events, suggesting BTX-A is a safe and effective treatment for patients with sialorrhea.

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Year:  2003        PMID: 14610139     DOI: 10.1212/wnl.61.9.1279

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  37 in total

Review 1.  Clozapine-induced sialorrhea: pathophysiology and management strategies.

Authors:  Samir Kumar Praharaj; Manu Arora; Sachin Gandotra
Journal:  Psychopharmacology (Berl)       Date:  2006-03-03       Impact factor: 4.530

2.  Management of symptoms in amyotrophic lateral sclerosis.

Authors:  Lisa S Thibodeaux; Amparo Gutierrez
Journal:  Curr Treat Options Neurol       Date:  2008-03       Impact factor: 3.598

Review 3.  Evidence for the effectiveness of botulinum toxin for sialorrhoea.

Authors:  D D Truong; R Bhidayasiri
Journal:  J Neural Transm (Vienna)       Date:  2008-02-04       Impact factor: 3.575

Review 4.  Amyotrophic lateral sclerosis: update for family physicians.

Authors:  Christen L Shoesmith; Michael J Strong
Journal:  Can Fam Physician       Date:  2006-12       Impact factor: 3.275

Review 5.  The option of sonographic guidance in Botulinum toxin injection for drooling in Parkinson's disease.

Authors:  Wolfgang H Jost
Journal:  J Neural Transm (Vienna)       Date:  2015-07-03       Impact factor: 3.575

6.  Botulinum toxin therapy: its use for neurological disorders of the autonomic nervous system.

Authors:  Dirk Dressler
Journal:  J Neurol       Date:  2012-08-10       Impact factor: 4.849

Review 7.  Drooling in Parkinson's disease: a review.

Authors:  Prachaya Srivanitchapoom; Sanjay Pandey; Mark Hallett
Journal:  Parkinsonism Relat Disord       Date:  2014-08-27       Impact factor: 4.891

8.  The use of botulinum toxin in the treatment of sialorrhea in parkinsonian disorders.

Authors:  María T Gómez-Caravaca; María T Cáceres-Redondo; Ismael Huertas-Fernández; Laura Vargas-González; Fátima Carrillo; Manuel Carballo; Pablo Mir
Journal:  Neurol Sci       Date:  2014-09-20       Impact factor: 3.307

Review 9.  [Treatment of sialorrhea with botulinum toxin: an overview].

Authors:  J Hagenah; K G Kahl; S Steinlechner; R Lencer; C Klein
Journal:  Nervenarzt       Date:  2005-04       Impact factor: 1.214

10.  Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis.

Authors:  João Costa; Maria Luz Rocha; Joaquim Ferreira; Teresinha Evangelista; Miguel Coelho; Mamede de Carvalho
Journal:  J Neurol       Date:  2008-02-19       Impact factor: 4.849

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