OBJECTIVE: / METHOD: The authors used the Frontal Systems Behavior Scale (FrSBe) to determine the frequency of frontal behavioral syndromes in 49 subjects with mild-to-moderate dementia and 23 subjects with severe dementia of Alzheimer disease (AD) and 23 healthy control (HC) participants. RESULTS: / CONCLUSIONS: Frontal behavior syndromes occurred with higher frequency in AD. Apathy and executive dysfunction were elevated both in mild-to-moderate and severe AD. Disinhibition was elevated only in severe AD. In AD, apathy was associated with difficulty in basic activities of daily living (ADL), whereas executive dysfunction was related to impairment in instrumental ADLs.
OBJECTIVE: / METHOD: The authors used the Frontal Systems Behavior Scale (FrSBe) to determine the frequency of frontal behavioral syndromes in 49 subjects with mild-to-moderate dementia and 23 subjects with severe dementia of Alzheimer disease (AD) and 23 healthy control (HC) participants. RESULTS: / CONCLUSIONS:Frontal behavior syndromes occurred with higher frequency in AD. Apathy and executive dysfunction were elevated both in mild-to-moderate and severe AD. Disinhibition was elevated only in severe AD. In AD, apathy was associated with difficulty in basic activities of daily living (ADL), whereas executive dysfunction was related to impairment in instrumental ADLs.
Authors: Joanne M Hamilton; David P Salmon; Rema Raman; Lawrence A Hansen; Eliezer Masliah; Guerry M Peavy; Douglas Galasko Journal: Alzheimers Dement Date: 2013-07-11 Impact factor: 21.566
Authors: Madison Niermeyer; Chad Gaudet; Paul Malloy; Irene Piryatinsky; Stephen Salloway; Petra Klinge; Athene Lee Journal: J Int Neuropsychol Soc Date: 2020-05-20 Impact factor: 2.892
Authors: S Christine You; Christine M Walsh; Louis A Chiodo; Robin Ketelle; Bruce L Miller; Joel H Kramer Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472
Authors: Guerry M Peavy; David P Salmon; Steven D Edland; Steven Tam; Lawrence A Hansen; Eliezer Masliah; Douglas Galasko; Joanne M Hamilton Journal: Am J Geriatr Psychiatry Date: 2013-03-13 Impact factor: 4.105