Literature DB >> 14608591

Morning pseudoneutropenia during clozapine treatment.

David Esposito1, Jérémie Aouillé, Frédéric Rouillon, Frédéric Limosin.   

Abstract

Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900/mm(3) in the morning and 2200-2700/mm(3) in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.

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Year:  2003        PMID： 14608591     DOI： 10.1080/15622970310029918

Source DB:  PubMed          Journal:  World J Biol Psychiatry        ISSN： 1562-2975            Impact factor:   4.132


  4 in total

Review 1.  Restarting clozapine after neutropenia: evaluating the possibilities and practicalities.

Authors:  Eromona Whiskey; David Taylor
Journal:  CNS Drugs       Date:  2007       Impact factor: 5.749

2.  Morning granulocytopenia in two patients with connective-tissue disease treated with oral corticosteroids.

Authors:  Hiroyuki Tamiya; Noboru Hagino; Akiko Okamoto; Kazuhiko Yamamoto
Journal:  BMJ Case Rep       Date:  2011-03-29

3.  Pseudoneutropenia in lymphangioleiomyomatosis (LAM) patients receiving sirolimus: evaluation in a 100 patient cohort.

Authors:  Vissagan Gopalakrishnan; Amanda M Jones; Patricia Julien-Williams; Tania Machado; Robert L Danner; Jeffrey J Swigris; Robert Paine; Jay N Lozier; Joel Moss
Journal:  ERJ Open Res       Date:  2018-03-20

4.  Utilization of G-CSF and GM-CSF as an alternative to discontinuation in clozapine-induced neutropenia or leukopenia: A case report and discussion.

Authors:  Allison Karst; Jonathan Lister
Journal:  Ment Health Clin       Date:  2018-08-30
  4 in total

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