Literature DB >> 14607334

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential.

Akinori Nakajima1, Ken Kataoka, Mei Hong, Masakiyo Sakaguchi, Nam-ho Huh.   

Abstract

A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.

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Year:  2003        PMID： 14607334     DOI： 10.1016/s0304-3835(03)00443-9

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  19 in total

1.  Screening and cloning for proteins transactivated by the PS1TP5 protein of hepatitis B virus: a suppression subtractive hybridization study.

Authors:  Jian-Kang Zhang; Long-Feng Zhao; Jun Cheng; Jiang Guo; Dan-Qiong Wang; Yuan Hong; Yu Mao
Journal:  World J Gastroenterol       Date:  2007-03-14       Impact factor: 5.742

2.  A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.

Authors:  Hitoshi Murata; Masakiyo Sakaguchi; Yu Jin; Yoshihiko Sakaguchi; Jun-ichiro Futami; Hidenori Yamada; Ken Kataoka; Nam-ho Huh
Journal:  J Biol Chem       Date:  2010-12-21       Impact factor: 5.157

Review 3.  The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity.

Authors:  David N Hauser; Christopher T Primiani; Mark R Cookson
Journal:  Curr Protein Pept Sci       Date:  2017       Impact factor: 3.272

4.  Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.

Authors:  Alexandra Beilina; Marcel Van Der Brug; Rili Ahmad; Sashi Kesavapany; David W Miller; Gregory A Petsko; Mark R Cookson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-11       Impact factor: 11.205

Review 5.  The mitochondrial kinase PINK1, stress response and Parkinson's disease.

Authors:  Marina Jendrach; Suzana Gispert; Filomena Ricciardi; Michael Klinkenberg; Rudolf Schemm; Georg Auburger
Journal:  J Bioenerg Biomembr       Date:  2009-12       Impact factor: 2.945

Review 6.  The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.

Authors:  Kelly Jean Thomas; Mark R Cookson
Journal:  Int J Biochem Cell Biol       Date:  2009-03-05       Impact factor: 5.085

7.  The kinase domain of mitochondrial PINK1 faces the cytoplasm.

Authors:  Chun Zhou; Yong Huang; Yufang Shao; Jessica May; Delphine Prou; Celine Perier; William Dauer; Eric A Schon; Serge Przedborski
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-07       Impact factor: 11.205

8.  The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway.

Authors:  Lu-Yu Zhou; Mei Zhai; Yan Huang; Sheng Xu; Tao An; Yun-Hong Wang; Rong-Cheng Zhang; Cui-Yun Liu; Yan-Han Dong; Man Wang; Li-Li Qian; Murugavel Ponnusamy; Yu-Hui Zhang; Jian Zhang; Kun Wang
Journal:  Cell Death Differ       Date:  2018-10-22       Impact factor: 15.828

9.  The PINK1/Parkin pathway regulates mitochondrial morphology.

Authors:  Angela C Poole; Ruth E Thomas; Laurie A Andrews; Heidi M McBride; Alexander J Whitworth; Leo J Pallanck
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-29       Impact factor: 11.205

10.  PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.

Authors:  Kei Okatsu; Toshihiko Oka; Masahiro Iguchi; Kenji Imamura; Hidetaka Kosako; Naoki Tani; Mayumi Kimura; Etsu Go; Fumika Koyano; Manabu Funayama; Kahori Shiba-Fukushima; Shigeto Sato; Hideaki Shimizu; Yuko Fukunaga; Hisaaki Taniguchi; Masaaki Komatsu; Nobutaka Hattori; Katsuyoshi Mihara; Keiji Tanaka; Noriyuki Matsuda
Journal:  Nat Commun       Date:  2012       Impact factor: 14.919
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