Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A mathematical model for elongation of a peptide chain.

Literature DB >> 14607290

A mathematical model for elongation of a peptide chain.

Abstract

A mathematical model is presented for the steps in the elongation process, and the steady-state elongation rate as a function of the amino acid concentrations is found. In addition, the reset sub-process of the elongation process is modeled. The rate of elongation of peptide chains is found to be a function of the concentration of the amino acid to be bound and the concentration of all other amino acids. In addition, the overall elongation rate depends on the concentrations of elongation factors.

Mesh：

Substances：
Amino Acids

Year: 2003 PMID： 14607290 DOI： 10.1016/S0092-8240(03)00076-4

Source DB: PubMed Journal: Bull Math Biol ISSN： 0092-8240 Impact factor: 1.758

Keyword Cloud
Cited

7 in total

A mathematical model for elongation of a peptide chain.

1. Ribosome kinetics and aa-tRNA competition determine rate and fidelity of peptide synthesis.

2. A systems view of the protein expression process.

3. Predictive biophysical modeling and understanding of the dynamics of mRNA translation and its evolution.

4. The origins of time-delay in template biopolymerization processes.

5. Codon usage variability determines the correlation between proteome and transcriptome fold changes.

Review 6. Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview.

7. A systems approach to model natural variation in reactive properties of bacterial ribosomes.