Literature DB >> 14607194

Inflated and contradictory category naming deficits in Alzheimer's disease?

Keith R Laws1, Verity C Leeson, Tim M Gale.   

Abstract

Although some studies have documented category-specific deficits in patients with Alzheimer's disease, others have not. One possible reason is that where control groups have been used in previous studies, they have performed at ceiling; and this may spuriously affect the incidence and type of deficit reported (especially with common statistical techniques such as z-scores). We examined this issue in 18 Alzheimer's patients and 26 elderly controls, who named two picture sets: a simple set that typically produces ceiling effects (Set 1) and one that produces a normal distribution in controls (Set 2). Sets 1 and 2 produced inconsistent and even contradictory deficits in the same patients. The results also show that ceiling effects may inflate the number of living thing deficits and hence, distort the reported ratio of living to nonliving cases.

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Year:  2003        PMID: 14607194     DOI: 10.1016/s0278-2626(03)00213-6

Source DB:  PubMed          Journal:  Brain Cogn        ISSN: 0278-2626            Impact factor:   2.310


  1 in total

Review 1.  Word-finding difficulty: a clinical analysis of the progressive aphasias.

Authors:  Jonathan D Rohrer; William D Knight; Jane E Warren; Nick C Fox; Martin N Rossor; Jason D Warren
Journal:  Brain       Date:  2007-10-18       Impact factor: 13.501

  1 in total

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