PURPOSE AND METHODS: The c-Met protein is significant for oncogenesis and angiogenesis within the c-Met/HGF/SF-mediator system. The aim of this study was the analysis of c-Met immunoexpression/-synthesis and microvessel density as parameters for angiogenesis and prognosis in 115 soft tissue sarcomas. RESULTS: C-Met could be detected by immunohistochemistry in 87% of sarcomas. In all, 60.9% of cases exhibited absent or faint expression of c-Met protein, and 39.1% high expression of c-Met protein with a correlation between tumor grading and c-Met immunoexpression. Using in situ hybridization with detection of c-met-mRNA-transcripts, c-Met protein synthesis within tumor cells could be demonstrated. A statistically significant correlation between c-Met immunoexpression and tumor microvessel density was found. No prognostic value of c-Met expression and microvessel density could be detected in 56 patients with clinical follow-up ( P=0.8506 and P=0.9329 for disease-free survival). CONCLUSIONS: The results underline a role of c-Met as an oncoprotein in soft tissue sarcomas with correlation between immunoexpression and grading. The statistically significant correlation between c-Met expression and microvessel density (as a parameter of tumor angiogenesis) suggests an angiogenic function of the c-Met/HGF/SF mediator system in malignant mesenchymal tumors.
PURPOSE AND METHODS: The c-Met protein is significant for oncogenesis and angiogenesis within the c-Met/HGF/SF-mediator system. The aim of this study was the analysis of c-Met immunoexpression/-synthesis and microvessel density as parameters for angiogenesis and prognosis in 115 soft tissue sarcomas. RESULTS:C-Met could be detected by immunohistochemistry in 87% of sarcomas. In all, 60.9% of cases exhibited absent or faint expression of c-Met protein, and 39.1% high expression of c-Met protein with a correlation between tumor grading and c-Met immunoexpression. Using in situ hybridization with detection of c-met-mRNA-transcripts, c-Met protein synthesis within tumor cells could be demonstrated. A statistically significant correlation between c-Met immunoexpression and tumor microvessel density was found. No prognostic value of c-Met expression and microvessel density could be detected in 56 patients with clinical follow-up ( P=0.8506 and P=0.9329 for disease-free survival). CONCLUSIONS: The results underline a role of c-Met as an oncoprotein in soft tissue sarcomas with correlation between immunoexpression and grading. The statistically significant correlation between c-Met expression and microvessel density (as a parameter of tumor angiogenesis) suggests an angiogenic function of the c-Met/HGF/SF mediator system in malignant mesenchymal tumors.
Authors: R Ferracini; M Olivero; M F Di Renzo; M Martano; C De Giovanni; P Nanni; G Basso; K Scotlandi; P L Lollini; P M Comoglio Journal: Oncogene Date: 1996-04-18 Impact factor: 9.867
Authors: M Tokunou; T Niki; K Eguchi; S Iba; H Tsuda; T Yamada; Y Matsuno; H Kondo; Y Saitoh; H Imamura; S Hirohashi Journal: Am J Pathol Date: 2001-04 Impact factor: 4.307
Authors: K Yamazaki; S Abe; H Takekawa; N Sukoh; N Watanabe; S Ogura; I Nakajima; H Isobe; K Inoue; Y Kawakami Journal: Cancer Date: 1994-10-15 Impact factor: 6.860
Authors: James I Geller; John P Perentesis; Xiaowei Liu; Charles G Minard; Rachel A Kudgus; Joel M Reid; Elizabeth Fox; Susan M Blaney; Brenda J Weigel Journal: Pediatr Blood Cancer Date: 2017-04-27 Impact factor: 3.167
Authors: K M Linton; Y Hey; E Saunders; M Jeziorska; J Denton; C L Wilson; R Swindell; S Dibben; C J Miller; S D Pepper; J A Radford; A J Freemont Journal: Br J Cancer Date: 2008-04-01 Impact factor: 7.640