[Renal lesions of paraproteinemias and fibrillary glomerulopathies].

The term "paraproteinemia" or dysproteinemia" refers to a group of diseases caused by specific proteins that very often leads to kidney disease. In these cases a kidney biopsy is often the first diagnostic procedure leading to the diagnosis of a systemic disease. Due to the very variable presentation of the kidney disease in paraproteinemias a diagnosis is often very difficult without specific clinical data. Therefore, we recommend systematic investigation of the kidney biopsy including routine immunohistochemical stains for kappa- and lambda-light chains and electron microscopy in elderly patients with proteinuric kidney disease of unknown origin. In the following we will briefly discuss renal manifestations and clinical symptoms in multiple myeloma with light- or heavy chain deposition (LCDD: light chain deposition disease, HCDD: heavy chain deposition disease), macroglobulinemia Waldenström (Morbus Waldenström), primary amyloidosis or so called monoclonal gammopathy of uncertain dignity (benign monoclonal gammopathy) and fibrillary glomerulopathies.