PURPOSE: We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia. METHODS: Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm2 for approximately 17 minutes. RESULTS: Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss. CONCLUSION: Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.
PURPOSE: We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia. METHODS: Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm2 for approximately 17 minutes. RESULTS: Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss. CONCLUSION: Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.
Authors: Jack E Burkhalter; Thomas M Atkinson; J Berry-Lawhorn; Stephen Goldstone; Mark H Einstein; Timothy J Wilkin; Jeannette Lee; David Cella; Joel M Palefsky Journal: Value Health Date: 2018-04-11 Impact factor: 5.725
Authors: Robert N Goldstone; Shirin R Hasan; Steven Drury; Teresa M Darragh; Annemieke van Zante; Stephen E Goldstone Journal: Int J Colorectal Dis Date: 2016-10-21 Impact factor: 2.571
Authors: J Corral; D Parés; F García-Cuyás; B Revollo; S Videla; A Chamorro; M Piñol; B Clotet; G Sirera Journal: Tech Coloproctol Date: 2019-07-23 Impact factor: 3.781