Literature DB >> 14605207

Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Rozalyn M Anderson1, Magda Latorre-Esteves1, Ana Rute Neves2, Siva Lavu1,3, Oliver Medvedik1, Christopher Taylor3, Konrad T Howitz3, Helena Santos2, David A Sinclair1.   

Abstract

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.

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Year:  2003        PMID： 14605207      PMCID： PMC4998187          DOI： 10.1126/science.1088697

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

Review 1.  Genetics and the specificity of the aging process.

Authors:  Siegfried Hekimi; Leonard Guarente
Journal:  Science       Date:  2003-02-28       Impact factor: 47.728

2.  An intervention resembling caloric restriction prolongs life span and retards aging in yeast.

Authors:  J C Jiang; E Jaruga; M V Repnevskaya; S M Jazwinski
Journal:  FASEB J       Date:  2000-11       Impact factor: 5.191

3.  Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.

Authors:  Rozalyn M Anderson; Kevin J Bitterman; Jason G Wood; Oliver Medvedik; Haim Cohen; Stephen S Lin; Jill K Manchester; Jeffrey I Gordon; David A Sinclair
Journal:  J Biol Chem       Date:  2002-03-07       Impact factor: 5.157

4.  13C NMR analysis of electrostatic interactions between NAD+ and active site residues of UDP-galactose 4-epimerase: implications for the activation induced by uridine nucleotides.

Authors:  Y Wei; J Lin; P A Frey
Journal:  Biochemistry       Date:  2001-09-18       Impact factor: 3.162

5.  The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress.

Authors:  A K Pahlman; K Granath; R Ansell; S Hohmann; L Adler
Journal:  J Biol Chem       Date:  2000-10-31       Impact factor: 5.157

6.  Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

Authors:  S Imai; C M Armstrong; M Kaeberlein; L Guarente
Journal:  Nature       Date:  2000-02-17       Impact factor: 49.962

7.  Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Authors:  Rozalyn M Anderson; Kevin J Bitterman; Jason G Wood; Oliver Medvedik; David A Sinclair
Journal:  Nature       Date:  2003-05-08       Impact factor: 49.962

8.  NAD-dependent DNA-binding activity of the bifunctional NadR regulator of Salmonella typhimurium.

Authors:  T Penfound; J W Foster
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

9.  Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.

Authors:  Marcella Fulco; R Louis Schiltz; Simona Iezzi; M Todd King; Po Zhao; Yoshihiro Kashiwaya; Eric Hoffman; Richard L Veech; Vittorio Sartorelli
Journal:  Mol Cell       Date:  2003-07       Impact factor: 17.970

10.  High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.

Authors:  Matt Kaeberlein; Alex A Andalis; Gerald R Fink; Leonard Guarente
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272
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  55 in total

Review 1.  Calorie restriction: what recent results suggest for the future of ageing research.

Authors:  Daniel L Smith; Tim R Nagy; David B Allison
Journal:  Eur J Clin Invest       Date:  2010-05       Impact factor: 4.686

Review 2.  Protective effects and mechanisms of sirtuins in the nervous system.

Authors:  Feng Zhang; Suping Wang; Li Gan; Peter S Vosler; Yanqin Gao; Michael J Zigmond; Jun Chen
Journal:  Prog Neurobiol       Date:  2011-09-10       Impact factor: 11.685

3.  Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer.

Authors:  Rachel Raynes; Jessica Brunquell; Sandy D Westerheide
Journal:  Genes Cancer       Date:  2013-03

Review 4.  Looking for putative functions of the Leishmania cytosolic SIR2 deacetylase.

Authors:  D Sereno; B Vergnes; F Mathieu-Daude; A Cordeiro da Silva; A Ouaissi
Journal:  Parasitol Res       Date:  2006-09-20       Impact factor: 2.289

5.  Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression.

Authors:  Weijing Cai; John Cijiang He; Li Zhu; Xue Chen; Sylvan Wallenstein; Gary E Striker; Helen Vlassara
Journal:  Am J Pathol       Date:  2007-06       Impact factor: 4.307

6.  The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis.

Authors:  Brendon J Gurd; Yuko Yoshida; James Lally; Graham P Holloway; Arend Bonen
Journal:  J Physiol       Date:  2009-02-23       Impact factor: 5.182

7.  Leptin signaling and Alzheimer's disease.

Authors:  Gurdeep Marwarha; Othman Ghribi
Journal:  Am J Neurodegener Dis       Date:  2012-11-18

8.  NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

Authors:  María Jiménez-Hidalgo; Carlos Santos-Ocaña; Sergio Padilla; José M Villalba; Guillermo López-Lluch; Alejandro Martín-Montalvo; Robin K Minor; David A Sinclair; Rafael de Cabo; Plácido Navas
Journal:  Aging Cell       Date:  2009-02-23       Impact factor: 9.304

9.  Nutrition, sirtuins and aging.

Authors:  Uwe Wenzel
Journal:  Genes Nutr       Date:  2006-06       Impact factor: 5.523

10.  Life span extension and neuronal cell protection by Drosophila nicotinamidase.

Authors:  Vitaly Balan; Gregory S Miller; Ludmila Kaplun; Karina Balan; Zhao-Zhong Chong; Faqi Li; Alexander Kaplun; Mark F A VanBerkum; Robert Arking; D Carl Freeman; Kenneth Maiese; Guri Tzivion
Journal:  J Biol Chem       Date:  2008-08-04       Impact factor: 5.157
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