STUDY OBJECTIVES: The guidelines of the National Lung Health Education Program for COPD screening proposed a shorter FVC maneuver (forced expiratory volume at 6 s of exhalation [FEV(6)]). Although reference values for FEV(6) are available from the third National Health and Nutrition Examination Survey, forced expiratory flow between 25% and 75% of FVC (FEF(25-75%)) reference values for the shorter 6-s maneuver are not available and are needed. In particular, calculation of largest observed volume during the first 6 s of an FVC maneuver (FVC(6)), from a shortened FVC maneuver, is necessary because the FEF(25-75%) measurement is based on a percentage of FVC or, for a shorter maneuver, FVC(6). DESIGN: We reanalyzed the raw volume-time curves from the third National Health and Nutrition Examination Survey to calculate FVC(6), forced expiratory volume at 0.5 s of exhalation, forced expiratory volume at 3 s of exhalation, ratio of the FEV(1) to largest observed volume during the first 6 s of an FVC maneuver expressed as a percentage (FEV(1)/FEV(6)%), and forced expiratory flow between 25% and 75% of the largest observed volume during the first 6 s of an FVC maneuver (FEF(25-75%6)) in addition to the previously reported values for FEV(1), FEV(6), and FEV(1)/FEV(6)%. PATIENTS OR PARTICIPANTS: Using the same normal, asymptomatic, nonsmoking reference population from a previous study, reference values for these parameters were derived from best values. RESULTS: A total of 2,261 white, 2,564 African-American, and 2,666 Mexican-American subjects aged 8 to 80 years were included in the analysis. Fifty-four subjects from the previous study were not included due to missing raw volume-time curves. CONCLUSIONS: These reference values, utilizing the FVC(6), provide investigators with the means of evaluating the relative merits of using the shorter FVC maneuver as a surrogate for the traditional FVC. They are needed particularly for calculating FEF(25-75%), as statistically significant differences were observed between the FEF(25-75%) and FEF(25-75%6).
STUDY OBJECTIVES: The guidelines of the National Lung Health Education Program for COPD screening proposed a shorter FVC maneuver (forced expiratory volume at 6 s of exhalation [FEV(6)]). Although reference values for FEV(6) are available from the third National Health and Nutrition Examination Survey, forced expiratory flow between 25% and 75% of FVC (FEF(25-75%)) reference values for the shorter 6-s maneuver are not available and are needed. In particular, calculation of largest observed volume during the first 6 s of an FVC maneuver (FVC(6)), from a shortened FVC maneuver, is necessary because the FEF(25-75%) measurement is based on a percentage of FVC or, for a shorter maneuver, FVC(6). DESIGN: We reanalyzed the raw volume-time curves from the third National Health and Nutrition Examination Survey to calculate FVC(6), forced expiratory volume at 0.5 s of exhalation, forced expiratory volume at 3 s of exhalation, ratio of the FEV(1) to largest observed volume during the first 6 s of an FVC maneuver expressed as a percentage (FEV(1)/FEV(6)%), and forced expiratory flow between 25% and 75% of the largest observed volume during the first 6 s of an FVC maneuver (FEF(25-75%6)) in addition to the previously reported values for FEV(1), FEV(6), and FEV(1)/FEV(6)%. PATIENTS OR PARTICIPANTS: Using the same normal, asymptomatic, nonsmoking reference population from a previous study, reference values for these parameters were derived from best values. RESULTS: A total of 2,261 white, 2,564 African-American, and 2,666 Mexican-American subjects aged 8 to 80 years were included in the analysis. Fifty-four subjects from the previous study were not included due to missing raw volume-time curves. CONCLUSIONS: These reference values, utilizing the FVC(6), provide investigators with the means of evaluating the relative merits of using the shorter FVC maneuver as a surrogate for the traditional FVC. They are needed particularly for calculating FEF(25-75%), as statistically significant differences were observed between the FEF(25-75%) and FEF(25-75%6).
Authors: Surya P Bhatt; Young-Il Kim; James M Wells; William C Bailey; Joe W Ramsdell; Marilyn G Foreman; Robert L Jensen; Douglas S Stinson; Carla G Wilson; David A Lynch; Barry J Make; Mark T Dransfield Journal: Ann Am Thorac Soc Date: 2014-03
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Authors: Diane R Gold; Augusto A Litonjua; Vincent J Carey; JoAnn E Manson; Julie E Buring; I-Min Lee; David Gordon; Joseph Walter; Georgina Friedenberg; John L Hankinson; Trisha Copeland; Heike Luttmann-Gibson Journal: Contemp Clin Trials Date: 2016-01-16 Impact factor: 2.226
Authors: Asli Gorek Dilektasli; Janos Porszasz; Richard Casaburi; William W Stringer; Surya P Bhatt; Youngju Pak; Harry B Rossiter; George Washko; Peter J Castaldi; Raul San Jose Estepar; James E Hansen Journal: Chest Date: 2016-07-22 Impact factor: 9.410
Authors: María Soler Artigas; Louise V Wain; Emmanouela Repapi; Ma'en Obeidat; Ian Sayers; Paul R Burton; Toby Johnson; Jing Hua Zhao; Eva Albrecht; Anna F Dominiczak; Shona M Kerr; Blair H Smith; Gemma Cadby; Jennie Hui; Lyle J Palmer; Aroon D Hingorani; S Goya Wannamethee; Peter H Whincup; Shah Ebrahim; George Davey Smith; Inês Barroso; Ruth J F Loos; Nicholas J Wareham; Cyrus Cooper; Elaine Dennison; Seif O Shaheen; Jason Z Liu; Jonathan Marchini; Santosh Dahgam; Asa Torinsson Naluai; Anna-Carin Olin; Stefan Karrasch; Joachim Heinrich; Holger Schulz; Tricia M McKeever; Ian D Pavord; Markku Heliövaara; Samuli Ripatti; Ida Surakka; John D Blakey; Mika Kähönen; John R Britton; Fredrik Nyberg; John W Holloway; Debbie A Lawlor; Richard W Morris; Alan L James; Cathy M Jackson; Ian P Hall; Martin D Tobin Journal: Am J Respir Crit Care Med Date: 2011-10-01 Impact factor: 21.405
Authors: Rogelio Perez-Padilla; Fernando C Wehrmeister; Bartolome R Celli; Maria Victorina Lopez-Varela; Maria Montes de Oca; Adriana Muiño; Carlos Talamo; Jose R Jardim; Gonzalo Valdivia; Carmen Lisboa; Ana Maria B Menezes Journal: PLoS One Date: 2013-08-01 Impact factor: 3.240