| Literature DB >> 14604821 |
Frédéric Adam1, Marie-Christine Bouton, Marie-Geneviève Huisse, Martine Jandrot-Perrus.
Abstract
The interaction of thrombin with platelet glycoprotein Ibalpha (GPIb alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb alpha with thrombin exosites I and II but differ markedly regarding how the two proteins interact. The possible consequences on thrombus formation of thrombin interacting with GPIb alpha are discussed in light of these new data.Entities:
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Year: 2003 PMID： 14604821 DOI： 10.1016/j.molmed.2003.09.009
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951