Literature DB >> 14604391

A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta.

Zhi-Liang Wei1, Alan P Kozikowski.   

Abstract

The most potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

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Year:  2003        PMID： 14604391     DOI： 10.1021/jo035140g

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

1.  PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.

Authors:  Hongyan Yuan; Jin Lu; Junfeng Xiao; Geeta Upadhyay; Rachel Umans; Bhaskar Kallakury; Yuhzi Yin; Michael E Fant; Levy Kopelovich; Robert I Glazer
Journal:  Cancer Res       Date:  2013-06-27       Impact factor: 12.701

2.  Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation.

Authors:  Claire B Pollock; Olga Rodriguez; Philip L Martin; Chris Albanese; Xin Li; Levy Kopelovich; Robert I Glazer
Journal:  PPAR Res       Date:  2010-12-27       Impact factor: 4.964

3.  A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice.

Authors:  Wei Chen; Rong Gao; Xinni Xie; Zhibing Zheng; Haijing Li; Song Li; Fangting Dong; Lili Wang
Journal:  Sci Rep       Date:  2015-05-06       Impact factor: 4.379

4.  Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist.

Authors:  Su-Jeong Lee; Mallesham Samala; Seo Yeon Woo; Dongyup Hahn; Dayoung Kim; Tara Man Kadayat; Kyungjin Jung; Jina Kim; Dong-Su Kim; Sugyeong Kwon; Shinae Kim; Kyung-Hee Kim; Sang-Jip Nam; Sung Jin Cho; Jungwook Chin
Journal:  ACS Omega       Date:  2018-02-15

5.  Mechanochemical Thiocyanation of Aryl Compounds via C-H Functionalization.

Authors:  Edson de Oliveira Lima Filho; Ivani Malvestiti
Journal:  ACS Omega       Date:  2020-12-14

6.  The PPARδ ligand GW501516 reduces growth but not apoptosis in mouse inner medullary collecting duct cells.

Authors:  Jordan Clark; Rania Nasrallah; Richard L Hébert
Journal:  PPAR Res       Date:  2009-03-04       Impact factor: 4.964

7.  Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.

Authors:  Elizabeth E Girroir; Holly E Hollingshead; Andrew N Billin; Timothy M Willson; Gavin P Robertson; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Journal:  Toxicology       Date:  2007-11-04       Impact factor: 4.571
  7 in total

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