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Literature DB >> 14602974

Cancer and aging: yin, yang, and p53.

Abstract

The author discusses a recent paper published in Nature that shows that a hyperactive allele of the tumor suppressor p53 leads to the development of some premature aging phenotypes in mice. This new discovery is discussed in light of previous findings related to mechanisms of aging.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 14602974 DOI： 10.1126/sageke.2002.1.pe1

Source DB: PubMed Journal: Sci Aging Knowledge Environ ISSN： 1539-6150

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Cited

12 in total

Review 1. Pathologies associated with the p53 response.

Authors: Andrei V Gudkov; Elena A Komarova
Journal: Cold Spring Harb Perspect Biol Date: 2010-04-07 Impact factor: 10.005

2. Trade-offs between cancer and other diseases: do they exist and influence longevity?

Authors: Svetlana V Ukraintseva; Konstantin G Arbeev; Igor Akushevich; Alexander Kulminski; Liubov Arbeeva; Irina Culminskaya; Lucy Akushevich; Anatoli I Yashin
Journal: Rejuvenation Res Date: 2010-08 Impact factor: 4.663

3. Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.

Authors: Ji Min Yu; Xiying Wu; Jeffrey M Gimble; Xiaoyan Guan; Michael A Freitas; Bruce A Bunnell
Journal: Aging Cell Date: 2011-02 Impact factor: 9.304

4. Inflammation and p53: A Tale of Two Stresses.

Authors: Andrei V Gudkov; Katerina V Gurova; Elena A Komarova
Journal: Genes Cancer Date: 2011-04

5. Oxidative Stress Increases the Number of Stress Granules in Senescent Cells and Triggers a Rapid Decrease in p21waf1/cip1 Translation.

Authors: Xian Jin Lian; Imed-Eddine Gallouzi
Journal: J Biol Chem Date: 2009-01-28 Impact factor: 5.157

6. Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.

Authors: Anatoli I Yashin; Svetlana V Ukraintseva; Igor V Akushevich; Konstantin G Arbeev; Alexander Kulminski; Lucy Akushevich
Journal: Mech Ageing Dev Date: 2008-03-25 Impact factor: 5.432

Cancer and aging: yin, yang, and p53.

Review 1. Pathologies associated with the p53 response.

2. Trade-offs between cancer and other diseases: do they exist and influence longevity?

3. Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow.

4. Inflammation and p53: A Tale of Two Stresses.

5. Oxidative Stress Increases the Number of Stress Granules in Senescent Cells and Triggers a Rapid Decrease in p21waf1/cip1 Translation.

6. Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.

7. Could stress granules be involved in age-related diseases?

8. Early life exposure to the 1918 influenza pandemic and old-age mortality by cause of death.

9. Studying health histories of cancer: a new model connecting cancer incidence and survival.

10. Effect of overexpression of estrogen receptors in osteoblasts.