Literature DB >> 14602927

Molecular flip-flops formed by overlapping Fis sites.

Paul N Hengen1, Ilya G Lyakhov, Lisa E Stewart, Thomas D Schneider.   

Abstract

The DNA-binding protein Fis frequently uses pairs of sites 7 or 11 base pairs (bp) apart. Two overlapping Fis sites separated by 11 bp are found in the Escherichia coli origin of chromosomal replication. Only one of these sites is bound by Fis at a time, so the structure is a molecular flip-flop that could direct alternative firing of replication complexes in opposite directions. Alternatively, the flip-flop could represent part of an on-off switch for replication. Because they can be used to create precise switched states, molecular flip-flops could be used as the basis of a novel molecular computer.

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Year:  2003        PMID： 14602927      PMCID： PMC275571          DOI： 10.1093/nar/gkg877

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  93 in total

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Journal:  Mol Microbiol       Date:  2001-04       Impact factor: 3.501

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Journal:  Mol Microbiol       Date:  1993-03       Impact factor: 3.501

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Authors:  H Hiasa; K J Marians
Journal:  J Biol Chem       Date:  1994-10-07       Impact factor: 5.157

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Journal:  J Mol Biol       Date:  1995-02-10       Impact factor: 5.469
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  8 in total

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Authors:  Xingmin Sun; Dale F Mierke; Tapan Biswas; Sang Yeol Lee; Arthur Landy; Marta Radman-Livaja
Journal:  Mol Cell       Date:  2006-11-17       Impact factor: 17.970

2.  Claude Shannon: biologist. The founder of information theory used biology to formulate the channel capacity.

Authors:  Thomas D Schneider
Journal:  IEEE Eng Med Biol Mag       Date:  2006 Jan-Feb

3.  A brief review of molecular information theory.

Authors:  Thomas D Schneider
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Authors:  Tania A Rozgaja; Julia E Grimwade; Maryam Iqbal; Christopher Czerwonka; Mansi Vora; Alan C Leonard
Journal:  Mol Microbiol       Date:  2011-09-14       Impact factor: 3.501

5.  Anatomy of Escherichia coli sigma70 promoters.

Authors:  Ryan K Shultzaberger; Zehua Chen; Karen A Lewis; Thomas D Schneider
Journal:  Nucleic Acids Res       Date:  2006-12-22       Impact factor: 16.971

6.  Low Affinity DnaA-ATP Recognition Sites in E. coli oriC Make Non-equivalent and Growth Rate-Dependent Contributions to the Regulated Timing of Chromosome Replication.

Authors:  Prassanna Rao; Tania A Rozgaja; Abdulaziz Alqahtani; Julia E Grimwade; Alan C Leonard
Journal:  Front Microbiol       Date:  2018-07-26       Impact factor: 5.640

7.  Discovery of Fur binding site clusters in Escherichia coli by information theory models.

Authors:  Zehua Chen; Karen A Lewis; Ryan K Shultzaberger; Ilya G Lyakhov; Ming Zheng; Bernard Doan; Gisela Storz; Thomas D Schneider
Journal:  Nucleic Acids Res       Date:  2007-10-05       Impact factor: 16.971

8.  Correlation between binding rate constants and individual information of E. coli Fis binding sites.

Authors:  Ryan K Shultzaberger; Lindsey R Roberts; Ilya G Lyakhov; Igor A Sidorov; Andrew G Stephen; Robert J Fisher; Thomas D Schneider
Journal:  Nucleic Acids Res       Date:  2007-07-07       Impact factor: 16.971
  8 in total

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