N Nasir1, R M Rainsbury. 1. Department of Oncoplastic Breast Surgery, Oncoplastic Breast Unit, Royal Hampshire County Hospital, Romsey Road, Winchester SO22 5DG, UK.
Abstract
AIMS: To compare the frequency of residual tumour in the cavity wall in patients with positive resection margins undergoing either immediate re-excision (IR) at the time of surgery or delayed re-excision (DR) to investigate the effects of recent surgery on the detection of residual disease. METHODS: Records of 125 patients who had undergone wide local excision with positive margins were examined. In 64 patients re-excision was performed immediately and in 61 it was delayed by 13-69 days. The presence or absence of residual disease in the re-excision specimens was recorded. RESULTS: Residual tumour was detected in 40/64 (62%) and 20/61 (33%) DR specimens (P<0.001). DR specimens contained areas of fibrosis, fat necrosis and foreign body giant cell changes. CONCLUSIONS: The detection of residual disease is significantly lower in DR compared to IR specimens. Local repair mechanisms may account for this difference.
AIMS: To compare the frequency of residual tumour in the cavity wall in patients with positive resection margins undergoing either immediate re-excision (IR) at the time of surgery or delayed re-excision (DR) to investigate the effects of recent surgery on the detection of residual disease. METHODS: Records of 125 patients who had undergone wide local excision with positive margins were examined. In 64 patients re-excision was performed immediately and in 61 it was delayed by 13-69 days. The presence or absence of residual disease in the re-excision specimens was recorded. RESULTS: Residual tumour was detected in 40/64 (62%) and 20/61 (33%) DR specimens (P<0.001). DR specimens contained areas of fibrosis, fat necrosis and foreign body giant cell changes. CONCLUSIONS: The detection of residual disease is significantly lower in DR compared to IR specimens. Local repair mechanisms may account for this difference.
Authors: Maximilian Präger; Marion Kiechle; Björn Stollenwerk; Christoph Hinzen; Jürgen Glatz; Matthias Vogl; Reiner Leidl Journal: PLoS One Date: 2018-06-01 Impact factor: 3.240
Authors: S S K Tang; F Rapisarda; A Nerurkar; P Osin; F MacNeill; I Smith; S Johnston; G Ross; K Mohammed; G P H Gui Journal: BJS Open Date: 2018-12-12
Authors: W B G Sanderink; L J A Strobbe; P Bult; M S Schlooz-Vries; S Lardenoije; D J Venderink; I Sechopoulos; N Karssemeijer; W Vreuls; R M Mann Journal: Breast Cancer Res Treat Date: 2020-08-01 Impact factor: 4.872