Literature DB >> 14602484

A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene.

David J Vandenbergh1, Michael D Grant, Virginia Severns.   

Abstract

The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine-transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.

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Year:  2003        PMID: 14602484     DOI: 10.1016/j.mcp.2003.07.003

Source DB:  PubMed          Journal:  Mol Cell Probes        ISSN: 0890-8508            Impact factor:   2.365


  2 in total

1.  Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure.

Authors:  Yi-Chen Chen; Vincent P Kelly; Stefanie V Stachura; George A Garcia
Journal:  RNA       Date:  2010-03-30       Impact factor: 4.942

Review 2.  The queuine micronutrient: charting a course from microbe to man.

Authors:  Claire Fergus; Dominic Barnes; Mashael A Alqasem; Vincent P Kelly
Journal:  Nutrients       Date:  2015-04-15       Impact factor: 5.717

  2 in total

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