Literature DB >> 1460244

Comparative metabolism of phenanthrene in the rat and guinea pig.

I Chu1, K M Ng, F M Benoit, D Moir.   

Abstract

In the present study the biotransformation of phenanthrene in the rat and guinea pig was investigated. 14C-labelled phenanthrene was administered by gavage in corn oil to Sprague-Dawley rats (10 mg/kg b.w./day) and guinea pigs (10 mg/kg b.w./day). Urine and feces were separately collected for the determination of the radioactivity content, and pooled urine was used for the analysis of metabolites. Phenanthrene was metabolized by the rat and guinea pig to free hydroxylated phenanthrenes and their conjugates. The percentages of conjugates, expressed as the total urinary radioactivity, were 39% glucuronides, 24% sulfates and 18% cysteinylglycine for rats; and 39% glucuronides, 23% sulfates and 28% cysteinylglycine for guinea pigs. Enzymatic hydrolysis of glucuronides and sulfates resulted in the formation of free 1,2-, 3,4- and 9,10-dihydrodiols of phenanthrene and 1-, 2-, 3-, and 4-hydroxyphenanthrene in both species.

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Year:  1992        PMID： 1460244     DOI： 10.1080/03601239209372809

Source DB:  PubMed          Journal:  J Environ Sci Health B        ISSN： 0360-1234            Impact factor:   1.990


  7 in total

1.  Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation.

Authors:  Yan Zhong; Steven G Carmella; J Bradley Hochalter; Silvia Balbo; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2010-11-04       Impact factor: 3.739

2.  Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene.

Authors:  J Bradley Hochalter; Yan Zhong; Shaomei Han; Steven G Carmella; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2011-01-13       Impact factor: 3.739

3.  Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation.

Authors:  Jing Wang; Yan Zhong; Steven G Carmella; J Bradley Hochalter; Diane Rauch; Andrew Oliver; Joni Jensen; Dorothy K Hatsukami; Pramod Upadhyaya; Stephen S Hecht; Cheryl L Zimmerman
Journal:  J Pharmacol Exp Ther       Date:  2012-06-06       Impact factor: 4.030

4.  Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers.

Authors:  Stephen S Hecht; J Bradley Hochalter; Steven G Carmella; Yan Zhang; Diane M Rauch; Naomi Fujioka; Joni Jensen; Dorothy K Hatsukami
Journal:  Biomarkers       Date:  2013-01-22       Impact factor: 2.658

5.  Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide.

Authors:  Stephen S Hecht; Jon Bradley Hochalter
Journal:  Mutagenesis       Date:  2014-07-21       Impact factor: 3.000

Review 6.  Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

Authors:  Carl-Elis Boström; Per Gerde; Annika Hanberg; Bengt Jernström; Christer Johansson; Titus Kyrklund; Agneta Rannug; Margareta Törnqvist; Katarina Victorin; Roger Westerholm
Journal:  Environ Health Perspect       Date:  2002-06       Impact factor: 9.031

7.  Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

Authors:  Yesha M Patel; Sungshim L Park; Steven G Carmella; Viviana Paiano; Natalie Olvera; Daniel O Stram; Christopher A Haiman; Loic Le Marchand; Stephen S Hecht
Journal:  PLoS One       Date:  2016-06-08       Impact factor: 3.240
  7 in total

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