Total synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B.

[reaction: see text] The highly potent anti-HIV natural product daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular S(N)2'-type cyclization to form the 2H-benzopyran core structure.