| Literature DB >> 14602020 |
Jonathan S Foot1, Gerard M P Giblin, Richard J K Taylor.
Abstract
[reaction: see text] The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Bäcklund reaction and an unusual Lewis acid-promoted cyclization step.Entities:
Year: 2003 PMID： 14602020 DOI： 10.1021/ol035786v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005