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Literature DB >> 14601653

The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins.

Zs Bosze¹, L Hiripi, J W Carnwath, H Niemann.

Abstract

Until recently, transgenic rabbits were produced exclusively by pronuclear microinjection which results in additive random insertional transgenesis; however, progress in somatic cell cloning based on nuclear transfer will soon make it possible to produce rabbits with modifications to specific genes by the combination of homologous recombination and subsequent prescreening of nuclear donor cells. Transgenic rabbits have been found to be excellent animal models for inherited and acquired human diseases including hypertrophic cardiomyopathy, perturbed lipoprotein metabolism and atherosclerosis. Transgenic rabbits have also proved to be suitable bioreactors for the production of recombinant protein both on an experimental and a commercial scale. This review summarizes recent research based on the transgenic rabbit model.

Entities: Disease Species

Mesh：

Substances：
Hormones
Peptides

Year: 2003 PMID： 14601653 DOI： 10.1023/a:1025816809372

Source DB: PubMed Journal: Transgenic Res ISSN： 0962-8819 Impact factor: 2.788

105 in total

1. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.

Authors: Y Huang; S W Schwendner; S C Rall; D A Sanan; R W Mahley
Journal: J Biol Chem Date: 1997-09-05 Impact factor: 5.157

2. Production of pigs transgenic for human regulators of complement activation using YAC technology.

Authors: G A Langford; E Cozzi; N Yannoutsos; R Lancaster; K Elsome; P Chen; D J White
Journal: Transplant Proc Date: 1996-04 Impact factor: 1.066

3. Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis.

Authors: X Peng; J W Griffith; R Han; C M Lang; J W Kreider
Journal: Am J Pathol Date: 1999-07 Impact factor: 4.307

4. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression.

Authors: J Fernandes; G Tardif; J Martel-Pelletier; V Lascau-Coman; M Dupuis; F Moldovan; M Sheppard; B R Krishnan; J P Pelletier
Journal: Am J Pathol Date: 1999-04 Impact factor: 4.307

5. Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations.

Authors: N Zinovieva; C Lassnig; D Schams; U Besenfelder; E Wolf; S Müller; L Frenyo; J Seregi; M Müller; G Brem
Journal: Transgenic Res Date: 1998-11 Impact factor: 2.788

6. Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbits.

Authors: L Hiripi; F Makovics; R Halter; M Baranyi; D Paul; J W Carnwath; Zs Bösze; H Niemann
Journal: DNA Cell Biol Date: 2003-01 Impact factor: 3.311

7. Production of transgenic rabbits, sheep and pigs by microinjection.

Authors: R E Hammer; V G Pursel; C E Rexroad; R J Wall; D J Bolt; K M Ebert; R D Palmiter; R L Brinster
Journal: Nature Date: 1985 Jun 20-26 Impact factor: 49.962

8. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.

Authors: R D Palmiter; R L Brinster; R E Hammer; M E Trumbauer; M G Rosenfeld; N C Birnberg; R M Evans
Journal: Nature Date: 1982-12-16 Impact factor: 49.962

9. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits.

Authors: G Brem; P Hartl; U Besenfelder; E Wolf; N Zinovieva; R Pfaller
Journal: Gene Date: 1994-11-18 Impact factor: 3.688

10. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

Authors: J Fan; J Wang; A Bensadoun; S J Lauer; Q Dang; R W Mahley; J M Taylor
Journal: Proc Natl Acad Sci U S A Date: 1994-08-30 Impact factor: 11.205

16 in total

Review 1. Modeling human neurodegenerative diseases in transgenic systems.

Authors: Miguel A Gama Sosa; Rita De Gasperi; Gregory A Elder
Journal: Hum Genet Date: 2011-12-14 Impact factor: 4.132

2. Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos.

Authors: Peter Chrenek; Dusan Vasicek; Alexander V Makarevich; Rastislav Jurcik; Karin Suvegova; Vladimir Parkanyi; Miroslav Bauer; Jan Rafay; Angelika Batorova; Rekha K Paleyanda
Journal: Transgenic Res Date: 2005-08 Impact factor: 2.788

3. Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.

Authors: Arata Honda; Michiko Hirose; Masanori Hatori; Shogo Matoba; Hiroyuki Miyoshi; Kimiko Inoue; Atsuo Ogura
Journal: J Biol Chem Date: 2010-07-29 Impact factor: 5.157

The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins.

1. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis.

2. Production of pigs transgenic for human regulators of complement activation using YAC technology.

3. Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis.

4. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression.

5. Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations.

6. Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbits.

7. Production of transgenic rabbits, sheep and pigs by microinjection.

8. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.

9. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits.

10. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

Review 1. Modeling human neurodegenerative diseases in transgenic systems.

2. Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos.

3. Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine.

4. High level expression of tissue-nonspecific alkaline phosphatase in the milk of transgenic rabbits.

5. Generation of SV40-transformed rabbit tracheal-epithelial-cell-derived blastocyst by somatic cell nuclear transfer.

6. The genetic structure of domestic rabbits.

7. Construction of a cytogenetically anchored microsatellite map in rabbit.

8. Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits.

Review 9. Transgenic rabbit models for studying human cardiovascular diseases.

Review 10. Rabbit Models for Studying Human Infectious Diseases.