K Okada1, T Hasegawa, R Yokoyama, Y Beppu, E Itoi. 1. Department of Orthopaedic Surgery, Akita University School of Medicine, Akita 010-8543, Japan. cshokada@med.akita-u.ac.jp
Abstract
AIMS: To clarify the prognostic relevance of rosette-like features and other clinicopathological and immunohistochemical variables in patients with osteosarcoma. METHODS: Clinicopathological and immunohistochemical variables were analysed in 131 patients with non-metastatic high grade conventional osteosarcoma, with particular attention to the prognostic impact of rosette-like features. RESULTS: Rosette-like features were present in 18 (14%) cases. Rosette-like features were significantly associated with the osteoblastic subtype, numerous osteoclast-like giant cells, moderate pleomorphism, frequent haemangiopericytoma-like vascular patterns, epithelioid cytological features, positive immunoreactivity for epithelial membrane antigen and CD56, and negative staining for cytokeratin. In a multivariate analysis, rosette-like features (relative risk (RR), 3.8), a poor chemotherapy effect (RR, 2.9), and a tumour size of 10 cm or more (RR, 2.8) were identified as unfavourable prognostic factors. CONCLUSIONS: Rosette-like features can easily be identified from routine histological slides and the relative risk in patients with non-metastatic, conventional osteosarcoma is as high as other well known prognostic factors, including large size and poor chemotherapy effect.
AIMS: To clarify the prognostic relevance of rosette-like features and other clinicopathological and immunohistochemical variables in patients with osteosarcoma. METHODS: Clinicopathological and immunohistochemical variables were analysed in 131 patients with non-metastatic high grade conventional osteosarcoma, with particular attention to the prognostic impact of rosette-like features. RESULTS: Rosette-like features were present in 18 (14%) cases. Rosette-like features were significantly associated with the osteoblastic subtype, numerous osteoclast-like giant cells, moderate pleomorphism, frequent haemangiopericytoma-like vascular patterns, epithelioid cytological features, positive immunoreactivity for epithelial membrane antigen and CD56, and negative staining for cytokeratin. In a multivariate analysis, rosette-like features (relative risk (RR), 3.8), a poor chemotherapy effect (RR, 2.9), and a tumour size of 10 cm or more (RR, 2.8) were identified as unfavourable prognostic factors. CONCLUSIONS: Rosette-like features can easily be identified from routine histological slides and the relative risk in patients with non-metastatic, conventional osteosarcoma is as high as other well known prognostic factors, including large size and poor chemotherapy effect.
Authors: M Rytting; P Pearson; A K Raymond; A Ayala; J Murray; A W Yasko; M Johnson; N Jaffe Journal: Clin Orthop Relat Res Date: 2000-04 Impact factor: 4.176
Authors: A J Provisor; L J Ettinger; J B Nachman; M D Krailo; J T Makley; E J Yunis; A G Huvos; D L Betcher; E S Baum; C T Kisker; J S Miser Journal: J Clin Oncol Date: 1997-01 Impact factor: 44.544
Authors: N Baldini; K Scotlandi; G Barbanti-Bròdano; M C Manara; D Maurici; G Bacci; F Bertoni; P Picci; S Sottili; M Campanacci Journal: N Engl J Med Date: 1995-11-23 Impact factor: 91.245