OBJECTIVES: The objective was to investigate the expression of interferon regulatory factors 1 (IRF-1) in human uterine endometrial carcinoma. METHODS: Formalin-fixed, paraffin-embedded, archival tissue specimens from 76 human endometrial carcinomas and stained with polyclonal anti-IRF-1 antibody, using immunohistochemistry, localization, and immunostaining, were evaluated quantitatively using the H score together with 30 normal endometrium and 16 postmenopausal endometrium. RESULTS: The expression of IRF-1 was highest in normal endometrium, and decreased with the grade of endometrioid adenocarcinoma from grade 1 to grade 3. Postmenopausal endometrium was virtually unstained. CONCLUSIONS: Expression of IRF-1 is altered in human endometrioid adenocarcinoma compared with normal endometrium and postmenopausal endometrium. The loss of IRF-1 expression does not contradict with the tumor-suppressor function. The intensity of IRF-1 expression in each grade of endometrioid adenocarcinoma could be useful prognostic and therapeutic indicators.
OBJECTIVES: The objective was to investigate the expression of interferon regulatory factors 1 (IRF-1) in human uterine endometrial carcinoma. METHODS:Formalin-fixed, paraffin-embedded, archival tissue specimens from 76 humanendometrial carcinomas and stained with polyclonal anti-IRF-1 antibody, using immunohistochemistry, localization, and immunostaining, were evaluated quantitatively using the H score together with 30 normal endometrium and 16 postmenopausal endometrium. RESULTS: The expression of IRF-1 was highest in normal endometrium, and decreased with the grade of endometrioid adenocarcinoma from grade 1 to grade 3. Postmenopausal endometrium was virtually unstained. CONCLUSIONS: Expression of IRF-1 is altered in humanendometrioid adenocarcinoma compared with normal endometrium and postmenopausal endometrium. The loss of IRF-1 expression does not contradict with the tumor-suppressor function. The intensity of IRF-1 expression in each grade of endometrioid adenocarcinoma could be useful prognostic and therapeutic indicators.
Authors: C N Jondle; K E Johnson; A A Uitenbroek; P A Sylvester; C Nguyen; W Cui; V L Tarakanova Journal: J Virol Date: 2020-06-16 Impact factor: 5.103
Authors: Wadzanai P Mboko; Horatiu Olteanu; Avijit Ray; Gang Xin; Eric J Darrah; Suresh N Kumar; Joseph M Kulinski; Weiguo Cui; Bonnie N Dittel; Stephen B Gauld; Vera L Tarakanova Journal: J Virol Date: 2015-12-30 Impact factor: 5.103
Authors: Wadzanai P Mboko; Bryan C Mounce; Joseph Emmer; Eric Darrah; Shailendra B Patel; Vera L Tarakanova Journal: J Virol Date: 2014-04-09 Impact factor: 5.103