Literature DB >> 14599563

Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes.

Patricia Fernández1, Maria Isabel Guillén, Francisco Gomar, Maria José Alcaraz.   

Abstract

Heme oxygenase-1 (HO-1) is implicated in the protection against tissue injury. We investigated the expression of this protein in cartilage sections and chondrocytes obtained from osteoarthritic patients. HO-1 was immunodetected in preparations from cartilage and also in chondrocytes cultured in the absence of stimulation. We found that HO-1 can be modulated by cytokines since the pro-inflammatory cytokines interleukin (IL)-1beta, IL-17 and tumour necrosis factor-alpha (TNF-alpha) down-regulated this protein, whereas the anti-inflammatory cytokine IL-10 exerted the opposite effect. Our results suggest a role for HO-1 as part of protective mechanisms against tissue injury in human cartilage.

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Year:  2003        PMID： 14599563     DOI： 10.1016/s0006-2952(03)00543-4

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  15 in total

1.  Localisation of heme oxygenase isoforms in allergic human nasal mucosa.

Authors:  Stephen Lo; Silvana Di Palma; Lisa Pitkin; Andrew W McCombe
Journal:  Eur Arch Otorhinolaryngol       Date:  2004-12-11       Impact factor: 2.503

2.  Identification and validation of novel adipokines released from primary human adipocytes.

Authors:  Stefan Lehr; Sonja Hartwig; Daniela Lamers; Susanne Famulla; Stefan Müller; Franz-Georg Hanisch; Claude Cuvelier; Johannes Ruige; Kristin Eckardt; D Margriet Ouwens; Henrike Sell; Juergen Eckel
Journal:  Mol Cell Proteomics       Date:  2011-09-26       Impact factor: 5.911

3.  HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.

Authors:  Karen E Iles; Dale A Dickinson; Amanda F Wigley; Nathan E Welty; Volker Blank; Henry Jay Forman
Journal:  Free Radic Biol Med       Date:  2005-04-09       Impact factor: 7.376

4.  Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels.

Authors:  Hellíada Vasconcelos Chaves; Danielle Rocha do Val; Kátia Alves Ribeiro; Jonas Cavalcante Lemos; Ricardo Basto Souza; Francisco Isaac Fernandes Gomes; Rodrigo Maranguape Silva da Cunha; Vicente de Paulo Teixeira Pinto; Gerardo Cristino Filho; Marcellus Henrique Loiola Ponte de Souza; Mirna Marques Bezerra; Gerly Anne de Castro Brito
Journal:  Inflamm Res       Date:  2018-01-23       Impact factor: 4.575

5.  Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes.

Authors:  Hiroyuki Ishitobi; Yohei Sanada; Yoshio Kato; Yasunari Ikuta; Sachi Shibata; Satoshi Yamasaki; Martin K Lotz; Kiminori Matsubara; Shigeru Miyaki; Nobuo Adachi
Journal:  Eur J Pharmacol       Date:  2018-04-17       Impact factor: 4.432

6.  Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction.

Authors:  Leo A B Joosten; Ruben L Smeets; Marije I Koenders; Liduine A M van den Bersselaar; Monique M A Helsen; Birgitte Oppers-Walgreen; Erik Lubberts; Yoichiro Iwakura; Fons A J van de Loo; Wim B van den Berg
Journal:  Am J Pathol       Date:  2004-09       Impact factor: 4.307

7.  Role of nuclear factor-kappaB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells.

Authors:  María José Alcaraz; Ana María Vicente; Amparo Araico; José N Dominguez; María Carmen Terencio; María Luisa Ferrándiz
Journal:  Br J Pharmacol       Date:  2004-07-12       Impact factor: 8.739

8.  Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.

Authors:  Karen E Iles; Marcienne M Wright; Marsha P Cole; Nathan E Welty; Lorraine B Ware; Michael A Matthay; Francisco J Schopfer; Paul R S Baker; Anupam Agarwal; Bruce A Freeman
Journal:  Free Radic Biol Med       Date:  2008-12-14       Impact factor: 7.376

9.  Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion.

Authors:  Masato Tachibana; Masanori Hashino; Takashi Nishida; Takashi Shimizu; Masahisa Watarai
Journal:  PLoS One       Date:  2011-09-16       Impact factor: 3.240

10.  The Role of Interleukin-4 and Interleukin-10 in Osteoarthritic Joint Disease: A Systematic Narrative Review.

Authors:  E M van Helvoort; E van der Heijden; J A G van Roon; N Eijkelkamp; S C Mastbergen
Journal:  Cartilage       Date:  2022 Apr-Jun       Impact factor: 3.117
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