| Literature DB >> 14598216 |
Ji Sun Lee1, Hyoung Ja Kim, Yong Sup Lee.
Abstract
A new flavonoid glucuronide, apigenin 7-O-beta-D-(4'-caffeoyl)glucuronide (1), and the known compound, apigenin 7-O-beta-D-glucurnoide, were isolated from the flowers of Chrysanthemum morifolium, along with five known flavonoids. The structure of 1 was elucidated by the aid of spectroscopic analyses. Among isolated compounds, apigenin 7-O-beta-D-(4"-caffeoyl)glucuronide showed strong HIV-1 integrase inhibitory activity (IC (50) = 7.2 +/- 3.4 microg/ml) and anti-HIV activity in a cell culture assay (EC (50) = 41.86 +/- 1.43 microg/ml) using HIV-I (IIIB) infected MT-4 cells.Entities:
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Year: 2003 PMID： 14598216 DOI： 10.1055/s-2003-43207
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352