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Literature DB >> 14597756

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery.

Abstract

Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to determine their origin and developmental pathway.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 14597756 PMCID： PMC228490 DOI： 10.1172/JCI20274

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

21 in total

1. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment.

Authors: O Annacker; O Burlen-Defranoux; R Pimenta-Araujo; A Cumano; A Bandeira
Journal: J Immunol Date: 2000-04-01 Impact factor: 5.422

Review 2. Regulatory T cells: key controllers of immunologic self-tolerance.

Authors: S Sakaguchi
Journal: Cell Date: 2000-05-26 Impact factor: 41.582

3. Twenty-first century Foxp3.

Authors: Anne O'Garra; Paulo Vieira
Journal: Nat Immunol Date: 2003-04 Impact factor: 25.606

Review 4. Regulatory T cells in autoimmmunity*.

Authors: E M Shevach
Journal: Annu Rev Immunol Date: 2000 Impact factor: 28.527

5. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Authors: S Sakaguchi; N Sakaguchi; M Asano; M Itoh; M Toda
Journal: J Immunol Date: 1995-08-01 Impact factor: 5.422

6. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.

Authors: L A Stephens; D Mason
Journal: J Immunol Date: 2000-09-15 Impact factor: 5.422

7. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.

Authors: T A Chatila; F Blaeser; N Ho; H M Lederman; C Voulgaropoulos; C Helms; A M Bowcock
Journal: J Clin Invest Date: 2000-12 Impact factor: 14.808

8. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.

Authors: Mindi R Walker; Deborah J Kasprowicz; Vivian H Gersuk; Angele Benard; Megan Van Landeghen; Jane H Buckner; Steven F Ziegler
Journal: J Clin Invest Date: 2003-11 Impact factor: 14.808

Review 9. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis.

Authors: Eleonora Gambineri; Troy R Torgerson; Hans D Ochs
Journal: Curr Opin Rheumatol Date: 2003-07 Impact factor: 5.006

10. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.

Authors: R S Wildin; F Ramsdell; J Peake; F Faravelli; J L Casanova; N Buist; E Levy-Lahad; M Mazzella; O Goulet; L Perroni; F D Bricarelli; G Byrne; M McEuen; S Proll; M Appleby; M E Brunkow
Journal: Nat Genet Date: 2001-01 Impact factor: 38.330

63 in total

Review 1. Tregs and transplantation tolerance.

Authors: Patrick T Walsh; Devon K Taylor; Laurence A Turka
Journal: J Clin Invest Date: 2004-11 Impact factor: 14.808

2. FOXP3 expression and nodal metastasis of breast cancer.

Authors: Yesim Gökmen-Polar; Mangesh A Thorat; Payal Sojitra; Rashmil Saxena; Sunil Badve
Journal: Cell Oncol (Dordr) Date: 2013-08-31 Impact factor: 6.730

Review 3. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications.

Authors: Lequn Li; Vassiliki A Boussiotis
Journal: J Mol Med (Berl) Date: 2006-09-14 Impact factor: 4.599

4. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.

Authors: Brygida Bisikirska; John Colgan; Jeremy Luban; Jeffrey A Bluestone; Kevan C Herold
Journal: J Clin Invest Date: 2005-09-15 Impact factor: 14.808

5. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.

Authors: Estelle Bettelli; Maryam Dastrange; Mohamed Oukka
Journal: Proc Natl Acad Sci U S A Date: 2005-03-24 Impact factor: 11.205

Review 6. Regulatory T cells and type 1 diabetes.

Authors: Brygida C Bisikirska; Kevan C Herold
Journal: Curr Diab Rep Date: 2005-04 Impact factor: 4.810

7. Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor.

Authors: Iris Bellinghausen; Bettina König; Ingo Böttcher; Jürgen Knop; Joachim Saloga
Journal: Immunology Date: 2005-09 Impact factor: 7.397

8. Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease.

Authors: Stephan Mielke; Katayoun Rezvani; Bipin N Savani; Raquel Nunes; Agnes S M Yong; John Schindler; Roger Kurlander; Victor Ghetie; Elizabeth J Read; Scott R Solomon; Ellen S Vitetta; A John Barrett
Journal: Blood Date: 2007-05-03 Impact factor: 22.113

9. CD8+CD28- cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients.

Authors: Bülent Karagöz; Oğuz Bilgi; Mahmut Gümüs; Alev Akyol Erikçi; Ozkan Sayan; Orhan Türken; Emin Gökhan Kandemir; Ahmet Oztürk; Mustafa Yaylaci
Journal: Med Oncol Date: 2009-01-16 Impact factor: 3.064

Review 10. Regulatory T Cells for More Targeted Immunosuppressive Therapies.

Authors: Hazim Allos; Basmah S Al Dulaijan; John Choi; Jamil Azzi
Journal: Clin Lab Med Date: 2018-12-20 Impact factor: 1.935