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Literature DB >> 14597755

Decreased elastin in vessel walls puts the pressure on.

Abstract

Mice haploinsufficient for elastin develop structural changes in vessel walls similar to those seen in patients with mutations in the elastin gene. A new study demonstrates that due to mechanical changes in the vessel wall, these animals exhibit increased mean arterial pressures. The results evoke the possibility that alterations in elastin may contribute to the development of essential hypertension in patients.

Entities: Disease Gene Species

Mesh：

Substances：
Elastin

Year: 2003 PMID： 14597755 PMCID： PMC228487 DOI： 10.1172/JCI20226

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

16 in total

1. Elastin and collagen accumulation in rabbit ascending aorta and pulmonary trunk during postnatal growth. Correlation of cellular synthetic response with medial tension.

Authors: D Y Leung; S Glagov; M B Mathews
Journal: Circ Res Date: 1977-09 Impact factor: 17.367

2. Transmural organization of the arterial media. The lamellar unit revisited.

Authors: J M Clark; S Glagov
Journal: Arteriosclerosis Date: 1985 Jan-Feb

3. Supravalvular aortic stenosis: a splice site mutation within the elastin gene results in reduced expression of two aberrantly spliced transcripts.

Authors: Z Urbán; V V Michels; S N Thibodeau; H Donis-Keller; K Csiszár; C D Boyd
Journal: Hum Genet Date: 1999-02 Impact factor: 4.132

4. Isolated supravalvular aortic stenosis: functional haploinsufficiency of the elastin gene as a result of nonsense-mediated decay.

Authors: Z Urbán; V V Michels; S N Thibodeau; E C Davis; J P Bonnefont; A Munnich; B Eyskens; M Gewillig; K Devriendt; C D Boyd
Journal: Hum Genet Date: 2000-06 Impact factor: 4.132

5. Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

Authors: Gilles Faury; Mylène Pezet; Russell H Knutsen; Walter A Boyle; Scott P Heximer; Sean E McLean; Robert K Minkes; Kendall J Blumer; Attila Kovacs; Daniel P Kelly; Dean Y Li; Barry Starcher; Robert P Mecham
Journal: J Clin Invest Date: 2003-11 Impact factor: 14.808

Decreased elastin in vessel walls puts the pressure on.

1. Elastin and collagen accumulation in rabbit ascending aorta and pulmonary trunk during postnatal growth. Correlation of cellular synthetic response with medial tension.

2. Transmural organization of the arterial media. The lamellar unit revisited.

3. Supravalvular aortic stenosis: a splice site mutation within the elastin gene results in reduced expression of two aberrantly spliced transcripts.

4. Isolated supravalvular aortic stenosis: functional haploinsufficiency of the elastin gene as a result of nonsense-mediated decay.

5. Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

6. Arterial hemodynamics in human hypertension.

7. Mechanical pressure versus intrinsic effects of hypertension on large arteries in humans.

Review 8. Role of arterial compliance in the physiopharmacological approach to human hypertension.

9. The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis.

Review 10. Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis.

1. Substantial expression of mature elastin in arterial constructs.

2. Tempol, a superoxide dismutase mimetic, prevents cerebral vessel remodeling in hypertensive rats.

3. Advances in biomimetic regeneration of elastic matrix structures.

4. Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization.

5. Copper nanoparticle cues for biomimetic cellular assembly of crosslinked elastin fibers.

6. Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors.