PURPOSE: To assess the expression of MMP (matrix metalloproteinase)-2 and -9 and TIMP (tissue inhibitors of metalloproteinases)-1, -2, and -3 in Sorsby fundus dystrophy. DESIGN: Cliniciopathological report. METHODS: A donor eye with a confirmed S181C mutation in the TIMP-3 gene and an age-matched normal donor eye were studied using in situ hybridization technique with MMP -2 and -9 and TIMP -1, -2, and -3 probes. RESULTS: There is a reduction of mRNA expression of MMP-2 and TIMP-3 in the Sorsby retinal pigment epithelium cells. CONCLUSIONS: Increased expression of TIMP-3 mRNA does not cause accumulation of TIMP-3 in the Bruch membrane of Sorsby fundus dystrophy nor is it likely to cause age-related macular degeneration.
PURPOSE: To assess the expression of MMP (matrix metalloproteinase)-2 and -9 and TIMP (tissue inhibitors of metalloproteinases)-1, -2, and -3 in Sorsby fundus dystrophy. DESIGN: Cliniciopathological report. METHODS: A donor eye with a confirmed S181C mutation in the TIMP-3 gene and an age-matched normal donor eye were studied using in situ hybridization technique with MMP -2 and -9 and TIMP -1, -2, and -3 probes. RESULTS: There is a reduction of mRNA expression of MMP-2 and TIMP-3 in the Sorsby retinal pigment epithelium cells. CONCLUSIONS: Increased expression of TIMP-3 mRNA does not cause accumulation of TIMP-3 in the Bruch membrane of Sorsby fundus dystrophy nor is it likely to cause age-related macular degeneration.
Authors: Abbi L Engel; YeKai Wang; Thomas H Khuu; Emily Worrall; Megan A Manson; Rayne R Lim; Kaitlen Knight; Aya Yanagida; Jian Hua Qi; Aravind Ramakrishnan; Richard G Weleber; Michael L Klein; David J Wilson; Bela Anand-Apte; James B Hurley; Jianhai Du; Jennifer R Chao Journal: Exp Eye Res Date: 2021-12-17 Impact factor: 3.770
Authors: Fred K Chen; Samuel McLenachan; Michael Edel; Lyndon Da Cruz; Peter J Coffey; David A Mackey Journal: J Clin Med Date: 2014-12-19 Impact factor: 4.241