Literature DB >> 14596929

The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling.

P R Vajjhala1, E Macmillan, T Gonda, M Little.   

Abstract

The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in transcriptional and post-transcriptional regulation.

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Year:  2003        PMID： 14596929     DOI： 10.1016/s0014-5793(03)01144-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization.

Authors:  William S Brooks; Sami Banerjee; David F Crawford
Journal:  Exp Cell Res       Date:  2006-12-14       Impact factor: 3.905

2.  The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron.

Authors:  Yeou-cherng Bor; Jennifer Swartz; Avril Morrison; David Rekosh; Michael Ladomery; Marie-Louise Hammarskjöld
Journal:  Genes Dev       Date:  2006-05-31       Impact factor: 11.361

Review 3.  Mammalian kidney development: principles, progress, and projections.

Authors:  Melissa H Little; Andrew P McMahon
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-05-01       Impact factor: 10.005

4.  WT1 regulates the development of the posterior taste field.

Authors:  Yankun Gao; Eneda Toska; Dane Denmon; Stefan G E Roberts; Kathryn F Medler
Journal:  Development       Date:  2014-05-06       Impact factor: 6.868

5.  The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.

Authors:  Jörg Hartkamp; Brian Carpenter; Stefan G E Roberts
Journal:  Mol Cell       Date:  2010-01-29       Impact factor: 17.970

6.  Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection.

Authors:  Jennifer L Gregg; Kathleen E Brown; Eric M Mintz; Helen Piontkivska; Gail C Fraizer
Journal:  BMC Cancer       Date:  2010-04-28       Impact factor: 4.430

7.  Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.

Authors:  Srividya Vaidyanathan; Pulari U Thangavelu; Pascal H G Duijf
Journal:  Target Oncol       Date:  2016-10       Impact factor: 4.493

8.  Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma.

Authors:  Tomoya Kanai; Zensho Ito; Yusuke Oji; Machi Suka; Sumiyuki Nishida; Kazuki Takakura; Mikio Kajihara; Masayuki Saruta; Shuichi Fujioka; Takeyuki Misawa; Tadashi Akiba; Hiroyuki Yanagisawa; Shigetaka Shimodaira; Masato Okamoto; Haruo Sugiyama; Shigeo Koido
Journal:  Oncol Lett       Date:  2018-06-13       Impact factor: 2.967

9.  Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).

Authors:  Charles E Patek; David G Brownstein; Stewart Fleming; Caroline Wroe; Lorraine Rose; Anna Webb; Rachel L Berry; Paul S Devenney; Marion Walker; Oliver D K Maddocks; Nicola J Lawrence; David J Harrison; Katrina M Wood; Colin G Miles; Martin L Hooper
Journal:  Transgenic Res       Date:  2007-11-27       Impact factor: 2.788

Review 10.  Wt1 in the kidney--a tale in mouse models.

Authors:  Derya Deniz Ozdemir; Peter Hohenstein
Journal:  Pediatr Nephrol       Date:  2013-11-18       Impact factor: 3.714
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