Literature DB >> 1459640

Lung injury by amiodarone, an antiarrhythmic drug, in male rats.

B Padmavathy1, S Niranjali, H Devaraj.   

Abstract

Administration of single dose (175 mg/kg body wt) of amiodarone dissolved in water through gavage for 3 weeks damaged the lung and changed the content of lung lavage. Activities of bronchoalveolar lavage (BAL) angiotensin converting enzyme (ACE) and lactate dehydrogenase (LDH) increased significantly. Also, the protein and lactate content of the lavage fluid increased significantly over the control. The drug also produced marked changes in morphology of the lung of experimental animals.

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Year:  1992        PMID： 1459640

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  4 in total

1.  Cytotoxicity of amiodarone in cultured human endothelial cells.

Authors:  B Baudin; B Bénéteau-Burnat; J Giboudeau
Journal:  Cardiovasc Drugs Ther       Date:  1996-11       Impact factor: 3.727

2.  Cyclophosphamide induced early biochemical changes in lung lavage fluid and alterations in lavage cell function.

Authors:  N Venkatesan; G Chandrakasan
Journal:  Lung       Date:  1994       Impact factor: 2.584

3.  Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats.

Authors:  Durairaj Punithavathi; Narayanan Venkatesan; Mary Babu
Journal:  Br J Pharmacol       Date:  2003-08       Impact factor: 8.739

4.  The protective effect of amiodarone in lung tissue of cecal ligation and puncture-induced septic rats: a perspective from inflammatory cytokine release and oxidative stress.

Authors:  Beyzagul Polat; Elif Cadirci; Zekai Halici; Yasin Bayir; Deniz Unal; Bulent Caglar Bilgin; Tugba Nurcan Yuksel; Serhat Vancelik
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-04-12       Impact factor: 3.000
  4 in total

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