Literature DB >> 14595576

Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves.

Shrishailappa Badami1, S A Manohara Reddy, E P Kumar, P Vijayan, B Suresh.   

Abstract

The total alkaloid fraction of the methanolic extract of Solanum pseudocapsicum leaves was tested for its in-vivo antitumor activity against Dalton's Lymphoma Ascites model in mice. The total alkaloid fraction at 2.5 and 5.0 mg/kg body weight doses exhibited antitumor activity as revealed by the significant increase in the mean survival time and the percentage increase in life span of tumor bearing mice. The antitumor activity observed may be due to its cytotoxic properties. However the treatment caused a significant decrease in the body weight below the normal indicating the toxicity of the treatment. Copyright 2003 John Wiley & Sons, Ltd.

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Year:  2003        PMID： 14595576     DOI： 10.1002/ptr.1229

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  6 in total

1.  In vitro cytotoxic screening of selected Saudi medicinal plants.

Authors:  Hussein Almehdar; Hossam M Abdallah; Abdel-Moneim M Osman; Essam A Abdel-Sattar
Journal:  J Nat Med       Date:  2011-09-28       Impact factor: 2.343

2.  Evaluation of Ceiba pentandra (L.) Gaertner bark extracts for in vitro cytotoxicity on cancer cells and in vivo antitumor activity in solid and liquid tumor models.

Authors:  Ravishankar Kumar; Nitesh Kumar; Grandhi V Ramalingayya; Manganahalli Manjunath Setty; Karkala Sreedhara Rangnath Pai
Journal:  Cytotechnology       Date:  2016-07-25       Impact factor: 2.058

3.  Tobacco rattle virus-induced PHYTOENE DESATURASE (PDS) and Mg-chelatase H subunit (ChlH) gene silencing in Solanum pseudocapsicum L.

Authors:  Hua Xu; Leifeng Xu; Panpan Yang; Yuwei Cao; Yuchao Tang; Guoren He; Suxia Yuan; Jun Ming
Journal:  PeerJ       Date:  2018-03-20       Impact factor: 2.984

Review 4.  Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds.

Authors:  Kumarappan Chidambaram; Taha Alqahtani; Yahia Alghazwani; Afaf Aldahish; Sivakumar Annadurai; Kumar Venkatesan; Kavitha Dhandapani; Ellappan Thilagam; Krishnaraju Venkatesan; Premalatha Paulsamy; Rajalakshimi Vasudevan; Geetha Kandasamy
Journal:  J Trop Med       Date:  2022-09-21

5.  Identification of a novel Calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-κB pathway.

Authors:  Ramar Perumal Samy; Peramaiyan Rajendran; Feng Li; Narayana Moorthy Anandi; Bradley G Stiles; Savarimuthu Ignacimuthu; Gautam Sethi; Vincent T K Chow
Journal:  PLoS One       Date:  2012-12-20       Impact factor: 3.240

6.  Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus.

Authors:  Shankar K Mitra; Neswi S Prakash; Ramachandran Sundaram
Journal:  Indian J Pharmacol       Date:  2012 Nov-Dec       Impact factor: 1.200
  6 in total

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